지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1,526 - 1,532 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Pulmonary arterial hypertension (PAH) is an orphan disease showing poor prognosis. The purpose of study was to evaluate clinical factors influencing outcomes in PAH. Materials and Methods: Patients who were diagnosed with PAH at a single center were reviewed retrospectively. Forty patients (34.9±14.5 years, 80% of female) were enrolled. Results: Causes were congenital heart diseasein 24 (60%), connective tissue disease in 8 (20%) and idiopathic PAH in 6 (15%). Sixteen patients (40%) were WHO functional class III or IV at the time of diagnosis. Twenty seven patients (67.5%) received molecular targeted therapy. During follow-up (53.6±45.5 months), 10 patients (25%) died and 1-, 2-, and 8 year survival rates were 91.3%, 78.7%, and 66.8%, respectively. As expected, mediansurvival of patients with functional class I or II were significantly longer than patients with III or IV (p=0.041). Interestingly, patients with molecular targeted therapy showed longer survival than conventional therapy (p=0.021). Conclusion: WHO functional class at the time of diagnosis was the strong predictor of survival, and molecular targeted therapy could significantly improve the survival. Therefore,early screening and intensive management would be crucial to improve the prognosis in the patient with PAH.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Badesch DB / 2009 / Diagnosis and assessment of pulmonary arterial hypertension / J Am Coll Cardiol 54 (1 Suppl) : S55 ~ S66
Barst RJ / 1994 / Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin / Ann Intern Med 121 : 409 ~ 415
Barst RJ / 1996 / A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension / N Engl J Med 334 : 296 ~ 3
Chin KM / 2008 / Pulmonary arterial hypertension / J Am Coll Cardiol 51 : 1527 ~ 1538
Dabestani A / 1987 / Evaluation of pulmonary artery pressure and resistance by pulsed Doppler echocardiography / Am J Cardiol 59 : 662 ~ 668
Barst RJ / 1994 / Survival in primary pulmonary hypertension with long-term continuous intravenous prostacyclin / Ann Intern Med 121 : 409 ~ 415
Barst RJ / 1996 / A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension / N Engl J Med 334 : 296 ~ 3
Chin KM / 2008 / Pulmonary arterial hypertension / J Am Coll Cardiol 51 : 1527 ~ 1538
Dabestani A / 1987 / Evaluation of pulmonary artery pressure and resistance by pulsed Doppler echocardiography / Am J Cardiol 59 : 662 ~ 668
이 논문의 저자 정보
최근 본 자료
댓글(0)
0