지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 824 - 830 (7page)
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초록· 키워드
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Purpose: The aim of this study was to evaluate the efficacy of re-irradiation in patients with recurrent gliomas and to identify subgroupsfor whom re-irradiation for recurrent gliomas is most beneficial.
Materials and Methods: We retrospectively reviewed 36 patients with recurrent or progressive gliomas who received re-irradiationbetween January 1996 and December 2011. Re-irradiation was offered to recurrent glioma patients with good performance or at least 6 months had passed after initial radiotherapy (RT), with few exceptions.
Results: Median doses of re-irradiation and initial RT were 45.0 Gy and 59.4 Gy, respectively. The median time interval between initial RT and re-irradiation was 30.5 months. Median overall survival (OS) and the 12-month OS rate were 11 months and 41.7%, respectively. In univariate analysis, Karnofsky performance status (KPS) ≥70 (p<0.001), re-irradiation dose ≥45 Gy (p=0.040), and longer time interval between initial RT and re-irradiation (p=0.040) were associated with improved OS. In multivariate analysis, KPS (p=0.030) and length of time interval between initial RT and re-irradiation (p=0.048) were important predictors of OS. A radiographicallysuspected mixture of radiation necrosis and progression after re-irradiation was seen in 5 patients.
Conclusion: Re-irradiation in conjunction with surgery could be a salvage treatment for selected recurrent glioma patients with good performance status and recurrence over a long time.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Wallner KE / 1989 / Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma / Int J Radiat Oncol Biol Phys 16:1405~1409
Brandes AA / 2009 / Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation With MGMT promoter methylation status / J Clin Oncol 27:1275~1279
Milano MT / 2010 / Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma / Int J Radiat Oncol Biol Phys 78:1147~1155
Dobelbower MC / 2011 / Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide / J Med Imaging Radiat Oncol 55:77~81
Sherriff J / 2013 / Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide / Br J Radiol 86:20120414
Brandes AA / 2009 / Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation With MGMT promoter methylation status / J Clin Oncol 27:1275~1279
Milano MT / 2010 / Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma / Int J Radiat Oncol Biol Phys 78:1147~1155
Dobelbower MC / 2011 / Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide / J Med Imaging Radiat Oncol 55:77~81
Sherriff J / 2013 / Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide / Br J Radiol 86:20120414
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