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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,034 - 1,037 (4page)
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초록· 키워드
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Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant to antibiotics and chronic infection. This study aims to identify susceptibilityof tigecycline in-vitro as a new therapeutic option for O. tsutsugamushi. Antibacterial activity of tigecycline against the O. tsutsugamushi was compared with doxycycline using flow cytometry assay. The inhibitory concentration 50 (IC50) was 3.59×10-3 μg/mL in doxycycline-treated group. Whereas in 0.71×10-3 μg/mL tigecycline-treated group. These findings indicate that tigecyclinemay be a therapeutic option for the treatment of scrub typhus.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Smadel JE / 1949 / Chloramphenicol (chloromycetin) in the treatment of tsutsugamushi disease (scrub typhus) / J Clin Invest 28(5 Pt 2):1196~1215
Prezyna AP / 1954 / Treatment of scrub typhus in the Pescadores Islands with chloramphenicol, aureomycin and terramycin / Am J Trop Med Hyg 3:608~614
Watt G / 1999 / Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand / Antimicrob Agents Chemother 43:2817~2818
Watt G / 1996 / Scrub typhus infections poorly responsive to antibiotics in northern Thailand / Lancet 348:86~89
Corwin A / 1999 / Scrub typhus and military operations in Indochina / Clin Infect Dis 29:940~941
Prezyna AP / 1954 / Treatment of scrub typhus in the Pescadores Islands with chloramphenicol, aureomycin and terramycin / Am J Trop Med Hyg 3:608~614
Watt G / 1999 / Azithromycin activities against Orientia tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand / Antimicrob Agents Chemother 43:2817~2818
Watt G / 1996 / Scrub typhus infections poorly responsive to antibiotics in northern Thailand / Lancet 348:86~89
Corwin A / 1999 / Scrub typhus and military operations in Indochina / Clin Infect Dis 29:940~941
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