지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 637 - 643 (7page)
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초록· 키워드
오류제보하기
Purpose: Nonsteroidal anti-inflammatory drugs are a mainstay for medical treatment of chronic lower back pain (CLBP). Increaseddose intervals for medication have been associated with increased patient adherence to prescriptions. The purpose of this clinical trial was to compare the efficacy and safety of a once daily dose of aceclofenac controlled release (CR) and a twice daily dose of aceclofenac for CLBP management.
Materials and Methods: A prospective, randomized, single center, open-label clinical trial was performed to compare the efficacy and safety of aceclofenac CR (200 mg once daily) to aceclofenac dose (100 mg twice daily). Fifty patients in each group were enrolledfor the study. The primary end point was Visual Analogue Scale (VAS) change at baseline to that at 2 weeks after medication and safety profiles. Also, change in quality of life measured by EuroQoL 5D (EQ-5D) and Oswestry Disability Index (ODI) functionalscore for the lumbar spine were also assessed.
Results: Within groups at pre- and post-treatment, there were significant VAS reductions for aceclofenac CR and aceclofenac (p= 0.028). EQ-5D increased significantly in both groups (p=0.037). ODI scores decreased significantly in both groups (p=0.012). However, there were no significant differences between aceclofenac CR and aceclofenac at pre- and post-treatment. Patients with aceclofenacCR showed significant increases in heartburn and indigestion and adverse gastrointestinal effects, compared to aceclofenac.
Conclusion: In patients with CLBP, aceclofenac CR and aceclofenac demonstrated significant symptomatic pain relief, improvementin quality of life and functional scores. Aceclofenac CR slightly increased gastrointestinal adverse effects, such as heartburn and indigestion.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Andrade NS / 2013 / Twenty-year perspective of randomized controlled trials for surgery of chronic nonspecific low back pain: citation bias and tangential knowledge / Spine J
Bae SK / 2012 / Pharmacokinetics of a new once-daily controlled-release formulation of aceclofenac in Korean healthy subjects compared with immediate-release aceclofenac and
Chaparro LE / 2014 / Opioids compared with placebo or other treatments for chronic low back pain: an update of the Cochrane Review / Spine (Phila Pa 1976) 39 : 556 ~ 563
Day RO / 2013 / Non-steroidal anti-inflammatory drugs (NSAIDs) / BMJ 346 : f3195 ~
Fairbank JC / 1980 / The Oswestry low back pain disability questionnaire / Physiotherapy 66 : 271 ~ 273
Bae SK / 2012 / Pharmacokinetics of a new once-daily controlled-release formulation of aceclofenac in Korean healthy subjects compared with immediate-release aceclofenac and
Chaparro LE / 2014 / Opioids compared with placebo or other treatments for chronic low back pain: an update of the Cochrane Review / Spine (Phila Pa 1976) 39 : 556 ~ 563
Day RO / 2013 / Non-steroidal anti-inflammatory drugs (NSAIDs) / BMJ 346 : f3195 ~
Fairbank JC / 1980 / The Oswestry low back pain disability questionnaire / Physiotherapy 66 : 271 ~ 273
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