지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 508 - 516 (9page)
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초록· 키워드
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Purpose: We investigated correlations of coronary plaque composition determined by virtual histology (VH) intravascular ultrasound (IVUS) and blood levels of biomarkers that represent the vulnerability of coronary plaques. Materials and Methods: Pre- and postprocedural blood levels of high sensitivity C-reactive protein,soluble CD40 ligand (sCD40L), matrix metalloproteinase-9, and neopterin were measured in 70 patients with stable angina (SA) or unstable angina (UA) who were undergoing percutaneous coronary intervention (PCI) for single lesions. We evaluated the data for correlations between these biomarkers and necrotic core contents in PCI target lesions analyzed by VH. Results: Clinical characteristics, IVUS, VH, and biomarker blood levels were not different between the SA and the UA group except for more frequent previous statin use (52.3% vs. 23.1%, p=0.017) and lower remodeling index in the SA group (0.98±0.09 vs. 1.10±0.070, p<0.001). Among the biomarkers evaluated, only pre-PCI neopterin level showed a weakly significant correlation with the absolute volume of the necrotic core (r=0.320, p=0.008). Pre- and post-PCI blood levels of sCD40L (r=0.220, p=0.072; r=0.231, p=0.062) and post-PCI blood level of neopterin (r=0.238, p=0.051) showed trends toward weakly positive correlations with the absolute volume of necrotic core. Conclusion: We found a weakly positive correlation between the pre-PCI neopterin level and necrotic core volume in the PCI-target lesion. The clinical implications of our findings need to be investigated in further studies.
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참고문헌 (43)
참고문헌 신청
Hermann A / 2001 / Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel / Platelets 12:74~82
Zirlik A / 2007 / CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1 / Circulation 115:1571~1580
Schönbeck U / 2001 / CD40 signaling and plaque instability / Circ Res 89:1092~1103
Nagase H / 2006 / Structure and function of matrix metalloproteinases and TIMPs / Cardiovasc Res 69:562~573
Galis ZS / 1994 / Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques / J Clin Invest 94:2493~2503
Zirlik A / 2007 / CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1 / Circulation 115:1571~1580
Schönbeck U / 2001 / CD40 signaling and plaque instability / Circ Res 89:1092~1103
Nagase H / 2006 / Structure and function of matrix metalloproteinases and TIMPs / Cardiovasc Res 69:562~573
Galis ZS / 1994 / Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques / J Clin Invest 94:2493~2503
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