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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 990 - 998 (9page)
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Purpose: HIV-infected patients are at increased risk for cardiovascular disease, which may be mediated in part by inflammation. This study aimed to evaluate the risk factors of carotid plaque, and clinical factors associated with carotid atherosclerosis measured by carotid intima-medial thickness (cIMT) in HIV patients. Materials and Methods: Clinical and cardiometabolic factors as well as cIMT were prospectively measured in 145 HIV-infected participants who had received combined antiretroviral therapy for ≥6 months. The mean value of the bilateral average cIMT level was used as Mean-IMT in the analysis, and the greatest value among the measured cIMT levels was used as Max-IMT. Results: Among 145 patients,34 (23.4%) had carotid plaque. Multivariate logistic regression analysis revealed three independent risk factors of carotid plaque: old age [odds ratio (OR) 6.16, 95% confidence interval (CI) 1.09-34.88; p=0.040], hypertension (OR 12.62, 95% CI 1.72-92.49; p=0.013) and higher low-density lipoprotein cholesterol (LDL-C) (OR 1.08, 95% CI 1.01-1.16; p=0.039). Levels of estimated glomerular filtration rate were inversely associated with Mean-IMT (r=-0.379, p<0.001) and Max-IMT (r=-0.389, p<0.001). Stepwise multivariate regression analyses revealed that age, total cholesterol and fasting glucose were positively correlated with cIMT, independent of other risk factors. Conclusion: The presence of hypertension,old age and a higher level of LDL-C were independent risk factors of carotid plaque among HIV-infected subjects.
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참고문헌 (20)
참고문헌 신청
Alberti KG / 2009 / Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National
Bonfanti P / 2010 / Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study / Curr HIV Res 8 : 165 ~ 171
Brannagan TH 3rd / 1997 / Retroviral-associated vasculitis of the nervous system / Neurol Clin 15 : 927 ~ 944
Carr A / 1999 / Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study / Lance
Chambless LE / 1997 / Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (A
Bonfanti P / 2010 / Is metabolic syndrome associated to HIV infection per se? Results from the HERMES study / Curr HIV Res 8 : 165 ~ 171
Brannagan TH 3rd / 1997 / Retroviral-associated vasculitis of the nervous system / Neurol Clin 15 : 927 ~ 944
Carr A / 1999 / Diagnosis, prediction, and natural course of HIV-1 protease-inhibitor-associated lipodystrophy, hyperlipidaemia, and diabetes mellitus: a cohort study / Lance
Chambless LE / 1997 / Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (A
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