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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 957 - 964 (8page)
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Purpose: To investigate the effect of pretreatment with intravenous nicorandil on the incidence of contrast-induced nephropathy (CIN) in patients with renal dysfunction undergoing coronary angiography. Materials and Methods: This randomized controlled multicenter study enrolled a total of 166 patients (nicorandil n=81; control n=85) with an estimated glomerular filtration rate <60 mL/min. Nicorandil 12 mg dissolved in 100 mL of 0.9% saline was administered intravenously for 30 minutes just prior to coronary angiography in the nicorandil group. The same volume of only saline was given to the control group. The primary endpoint was the incidence of CIN, defined as >0.5 mg/dL increase or >25% rise in serum creatinine (SCr) concentration within 48 hours of contrast exposure compared to baseline. Results: The final analysis included 149 patients (nicorandil n=73; control n=76). The baseline characteristics and the total volume of the used contrast (Iodixanol, 125.6±69.1 mL vs. 126.9±74.6 mL, p=0.916) were similar between the two groups. The incidence of CIN also did not differ between the nicorandil and control groups (6.8% vs. 6.6%, p=0.794). There was no difference between the two groups in the relative change in SCr from baseline to peak level within 48 hours after coronary angiography (-1.58±24.07% vs. 0.96±17.49%, p=0.464), although the nicorandil group showed less absolute change in SCr than the control group (-0.01±0.43 mg/mL vs. 0.02±0.31 mg/mL, p=0.005). Conclusion:Prophylactic intravenous infusion of nicorandil did not decrease the incidence of CIN in patients with renal dysfunction undergoing coronary angiography.
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참고문헌 (24)
참고문헌 신청
Brenner BM / 1989 / Endothelium-dependent vascular responses. Mediators and mechanisms / J Clin Invest 84 : 1373 ~ 1378
Brezis M / 1991 / Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys / J Clin Invest 88 : 390 ~ 395
Dangas G / 2005 / Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables / Am J Cardiol 95 :
Ellis JH / 2009 / Reducing the risk of contrast-induced nephropathy: a perspective on the controversies / AJR Am J Roentgenol 192 : 1544 ~ 1549
Fujisaki K / 2003 / Infusion of radiocontrast agents induces exaggerated release of urinary endothelin in patients with impaired renal function / Clin Exp Nephrol 7 : 279 ~
Brezis M / 1991 / Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys / J Clin Invest 88 : 390 ~ 395
Dangas G / 2005 / Contrast-induced nephropathy after percutaneous coronary interventions in relation to chronic kidney disease and hemodynamic variables / Am J Cardiol 95 :
Ellis JH / 2009 / Reducing the risk of contrast-induced nephropathy: a perspective on the controversies / AJR Am J Roentgenol 192 : 1544 ~ 1549
Fujisaki K / 2003 / Infusion of radiocontrast agents induces exaggerated release of urinary endothelin in patients with impaired renal function / Clin Exp Nephrol 7 : 279 ~
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