지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 832 - 838 (7page)
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Purpose: The association between Helicobacter pylori (H. pylori) and blood ammonia levels in cirrhotic patients is controversial. We aimed to clarify this controvercy by performing a meta-analysis of published studies. Materials and Methods:We searched PubMed, EMBASE and Cochrane library for studies which explored the association between H. pylori and blood ammonia levels in cirrhotic patients before May 2012. Six cohort studies involved in 632 H. pylori positive and 396 H. pylori negative cirrhotic patients were eligible for our analysis. The summary estimates were presented as standard means differences (SMD) and 95% confidence intervals (CI) from individual studies. Results: Overall, there was significant association between H. pylori infection and the elevated blood ammonia levels in cirrhotic patients (SMD=0.34, 95% CI=0.21-0.47, I2=42.1%). Sensitivity analysis further confirmed this association. Subgroup analysis showed that the association was found only in Asian ethnicity, but not in Caucasian ethnicity. Conclusion:H. pylori infection is associated with elevated blood ammonia levels in cirrhotic patients, and more large scale studies and stratify analysis are warranted in order to further evaluate this association.
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참고문헌 (25)
참고문헌 신청
Abdel-Hady H / 2007 / Helicobacter pylori infection in hepatic encephalopathy: relationship to plasma endotoxins and blood ammonia / Hepatol Res 37 : 1026 ~ 1033
Begg CB / 1994 / Operating characteristics of a rank correlation test for publication bias / Biometrics 50 : 1088 ~ 1101
Chakrabarti P / 2002 / Helicobacter pylori, gastric juice, and arterial ammonia levels in patients with cirrhosis / J Clin Gastroenterol 34 : 578 ~ 581
Chen SJ / 2008 / Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients / World J Gastroenterol 14 : 1914 ~ 1918
Dasani BM / 1998 / Analysis of risk factors for chronic hepatic encephalopathy: the role of Helicobacter pylori infection / Am J Gastroenterol 93 : 726 ~ 731
Begg CB / 1994 / Operating characteristics of a rank correlation test for publication bias / Biometrics 50 : 1088 ~ 1101
Chakrabarti P / 2002 / Helicobacter pylori, gastric juice, and arterial ammonia levels in patients with cirrhosis / J Clin Gastroenterol 34 : 578 ~ 581
Chen SJ / 2008 / Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients / World J Gastroenterol 14 : 1914 ~ 1918
Dasani BM / 1998 / Analysis of risk factors for chronic hepatic encephalopathy: the role of Helicobacter pylori infection / Am J Gastroenterol 93 : 726 ~ 731
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