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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 159 - 167 (9page)
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초록· 키워드
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Prostate cancer is one of the most common non-skin cancers in men. Armeniacae Amarum Semen has traditionally been used for the treatment of inflammation diseases, leprosy, leucoderma, and tumors. Apoptosis, which is also known as programmed cell death, is an important mechanism in cancer treatment.
Objectives : We observed whether an aqueous extract of Armeniacae Amarum Semen induces apoptotic cell death in human DU145 prostate cancer cells.
Methods : We treated DU145 cells with Armeniacae Amarum Semen extract and investigated characteristics of apoptosis. And investigated whether treated with Armeniacae Amarum Semen extract increased Bax mRNA expression, Bcl-2 mRNA expression, caspase-3 enzyme activity and their protein level.
Results : We have shown that Armeniacae Amarum Semen extract can induce apoptotic cell death in human DU145 prostate cancer cells by caspase-3 activation through the down-regulation on Bcl-2 expression and the up-regulation on Bax expression.
Conclusions : It can be expected that an aqueous extract of Armeniacae Amarum Semen may offer a valuable means for the treatment of prostate cancers.
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참고문헌 (31)
참고문헌 신청
Landis SH / 1999 / Cancer statistics / CA Cancer J Clin 49:8~31
Pak JU / 1999 / J Kor Orient Oncol 5:137~150
황대룡 / 2003 / 행인의 알레르기 천식 효과에 대한 연구 / 대한본초학회지 18(2):20~208
Fukuta T / 2003 / Anti-tumor promoting effect of glycosides from Prunus persica seeds / Biol Pharm Bull 26:271~273
Shim BS / 2000 / J Kor Orient Oncol 6:19~28
Pak JU / 1999 / J Kor Orient Oncol 5:137~150
황대룡 / 2003 / 행인의 알레르기 천식 효과에 대한 연구 / 대한본초학회지 18(2):20~208
Fukuta T / 2003 / Anti-tumor promoting effect of glycosides from Prunus persica seeds / Biol Pharm Bull 26:271~273
Shim BS / 2000 / J Kor Orient Oncol 6:19~28
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