메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한한방안이비인후피부과학회 한방안이비인후피부과학회지 한방안이비인후피부과학회지 제26권 제4호
발행연도
2013.1
수록면
1 - 14 (14page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Objectives : The purpose of this study is to investigate effects of Syzygium aromaticum (SAE) spread on the allergic contact dermatitis caused by 2,4-dinitro-chlorobezene (DNCB). Methods : Forty-two mice were divided into six groups ; normal, negative control (DNCB-treated), positive control (DNCB + 1% pimecrolimus), experimental group Ⅰ, Ⅱ and Ⅲ. control and experimental groups were induced allergic contact dermatitis by DNCB. Experimental group Ⅰ(DNCB + 0.2% SAE), Ⅱ(DNCB + 1% SAE)and Ⅲ(DNCB + 5% SAE) were spread SAE and positive control was spread the 1% pimecrolimus. In this study, effect of SAE on clinical aspects on the skin, histopathological change, the blood level of IgE, cytokines,histamine were investigated. In addition, effect of SAE on spleen CD4+/CD8+ T cell subset was investigated. Results : 1. In experimental group Ⅰ, Ⅱ and Ⅲ, erythemas and edema were more reduced than negative control. 2. In experimental group Ⅰ, Ⅱ and Ⅲ inflammatory edema and the numbers of infiltrated inflammatory cells were more reduced than negative control. 3. In experimental group Ⅰ, Ⅱ and Ⅲ, clinical skin score was more reduced than negative control. 4. In experimental group Ⅱ and Ⅲ, the thickness of skin was statistically significant reduced than negative control. 5. In experimental group Ⅱ and Ⅲ, histamine release was statistically significant reduced than negative control in dose-dependantly. 6. In experimental group Ⅱ and Ⅲ, cytokines (IL-1β, TNF-α, IL-4, IL-6, IL-10) were statistically significant reduced than negative control in dose-dependantly. 7. In experimental group Ⅰ, Ⅱ and Ⅲ, the level of total IgE was statistically significant reduced than negative control in dose-dependantly. 8. In experimental group Ⅲ, CD4+ and CD8+ T cells were statistically significant decreased similar to the positive control. Conclusions : According to above experiments, Syzygium aromaticum(SAE) was effective on allergic contact dermatitis.

목차

등록된 정보가 없습니다.

참고문헌 (29)

참고문헌 신청

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0