지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 1 - 10 (10page)
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Objectives : To investigate the effects of DL-HGF to hair growth activity in mouse, various kinds of
ethosome and liposome formulations entrapped DL-HGF were produced and this study was carried out.
Methods : The B16/BL6 mice were classified into five groups: vehicle control (Con) group, Et-1-applied
group, Et-2-applied group, LP-1-applied group, LP-2-applied group. Active hair growth (anagen) was induced
in the back skin by application of a wax–osin mixture with subsequent depilation and the activity of hair
growth was measured by macroscopic observation and histology.
Results : In vehicle control group, there was no hair growth activity during experiment period. In
Et-1-applied group, the rate of hair growth was about 100%, LP-1-applied group and Et-2-applied group
showed 70-80% and 40-50% of hair growth rates, respectively. The rate of hair growth of LP-2-applied
group was lower than other applied groups (20-30%). In H/E staining, Numerous hair folicles and hair
shafts were observed in Et-1-applied group and other groups showed lower level of hair folicles and hair
shafts formation than Et-1-applied group.
Conclusion : Et-1 formulation showed highest hair growth activity than other ethosome and liposome
formulations entrapped DL-HGF.
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참고문헌 (28)
참고문헌 신청
Cevc G / 1992 / Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force / Biochim. Biophys. Acta 1104 : 226 ~ 232
Cevc G / 1996 / Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery / Crit. Rev. The
Dayan N / 2000 / Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes / Biomaterials 21 : 1879 ~ 1885
Egbaria K / 1991 / Topical application of liposomally entrapped cyclosporin evaluated by in vitro diffusion studies with human skin / Skin Pharmacol. Phys 4 : 21 ~ 28
Heim M / 1995 / Lateral electrical conductivity of mica-supported lipid bilayer membranes measured by scanning tunneling microscopy / Biophys. J 69 : 489 ~ 497
Cevc G / 1996 / Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery / Crit. Rev. The
Dayan N / 2000 / Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes / Biomaterials 21 : 1879 ~ 1885
Egbaria K / 1991 / Topical application of liposomally entrapped cyclosporin evaluated by in vitro diffusion studies with human skin / Skin Pharmacol. Phys 4 : 21 ~ 28
Heim M / 1995 / Lateral electrical conductivity of mica-supported lipid bilayer membranes measured by scanning tunneling microscopy / Biophys. J 69 : 489 ~ 497
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