지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 1 - 11 (11page)
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Objective : Paeoniae radix alba(PRA) can enrich the blood and regulate menstruation, astringe yin and arrest sweating, calm the liver and arrest pain. This study was designed to investigate effects of PRA on skin whitening and elasticity using melanoma cells.
Methods : In this experiment, effect of PRA on cell viability, inhibition of melanin synthesis and inhibitory effect on tyrosinase and elastase.
Results : 1. More than 1,000 ㎍/㎖ of PRA treated group showed lowered proliferation rates significantly compared to non-treated control group.
2. All of treated groups were lower levels of melanin synthesis respectively.
3. PRA did not show inhibitory effect on tyrosinase activities in vitro. But, PRA suppressed tyrosinase activities in B16F10 cells significantly.
4. PRA suppressed elastse type 1 activities in dose-dependent manner in vitro. But, PRA slightly suppressed elastase type 4 activities in vitro, and PRA also slightly suppressed elastase activities in vivo.
Conclusion : These results suggest that PRA can inhibit melanin synthesis through ihhibitory action on tyrosinase activity and inhibt elastase activity, and also suggest that these results can be used for the study on maintaining skin whitening or elasticity.
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참고문헌 (34)
참고문헌 신청
Chakraborty A. K. / 1998 / Effect of arbutin on melanogenic proteins in human / Pigment Cell Res 11 : 206 ~ 212
Funasaka Y / 1999 / The depogmenting effect of alpha tocopheryl ferulate on human melanoma cells / Br. J. Dermatol 141 (1) : 20 ~ 29
Hosei J / 1985 / Regulation of melanin synthesis of B16 mouse melanoma cells by 1α, 25-Dihydroxyvitamin D3 and Retinoic Acid / Cancer Res 45 (4) : 1474 ~ 1478
Ikeda T / 1990 / Function and skin depigmental activity of crude drugs / Fragrance J 6 : 56 ~
James, A. E. K / 1996 / Inhibition of human leukocyte and porcrin pancreatic elastase by homologues of bovine pancreatic tyrosin inhibitors / Bio-chemistry 35 : 9090 ~ 9096
Funasaka Y / 1999 / The depogmenting effect of alpha tocopheryl ferulate on human melanoma cells / Br. J. Dermatol 141 (1) : 20 ~ 29
Hosei J / 1985 / Regulation of melanin synthesis of B16 mouse melanoma cells by 1α, 25-Dihydroxyvitamin D3 and Retinoic Acid / Cancer Res 45 (4) : 1474 ~ 1478
Ikeda T / 1990 / Function and skin depigmental activity of crude drugs / Fragrance J 6 : 56 ~
James, A. E. K / 1996 / Inhibition of human leukocyte and porcrin pancreatic elastase by homologues of bovine pancreatic tyrosin inhibitors / Bio-chemistry 35 : 9090 ~ 9096
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