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- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제11권 제4호
- 발행연도
- 2012.1
- 수록면
- 111 - 117 (7page)
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Vitamin D is not a true vitamin but a fat-soluble steroid prohormone that has long been known for its important and diverse role in the biological system. Many studies have revealed that vitamin D deficiency is linked with an increased risk of autoimmune diseases, cardiovascular diseases, cancers, type II diabetes and infectious diseases. Vitamin D3 is transformed to its active form, 1, 25-dihydroxyvitamin D3, through metabolisms in the liver and kidney. 1, 25-dihydroxyvitamin D3 interacts with its vitamin D receptor, and the brain is now known to have vitamin D receptors and 1α-hydroxylase. Several lines of evidences suggest vitamin D deficiency is associated with cognitive impairment and dementia, however, its position in cognitive function is still in its infancy. Vitamin D deficiency is a reversible condition and can be easily treated with supplements. Randomized controlled trials of vitamin D supplementation in patients with neurodegenerative conditions are needed.
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참고문헌 (48)
참고문헌 신청
Riaz S / 1999 / A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats / Diabetologia 42:1308~1313
Gezen-Ak D / 2007 / Association between vitamin D receptor gene polymorphism and alzheimer’s disease / Tohoku J Exp Med 212:275~282
Masoumi A / 2009 / 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of alzheimer’s disease patients / J Alzheimers Dis 17:703~17
Taniura H / 2006 / Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons / J Neurosci Res 83:1179~1189
Lin AM / 2005 / Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS / Ann N Y Acad Sci 1053:319~329
Gezen-Ak D / 2007 / Association between vitamin D receptor gene polymorphism and alzheimer’s disease / Tohoku J Exp Med 212:275~282
Masoumi A / 2009 / 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of alzheimer’s disease patients / J Alzheimers Dis 17:703~17
Taniura H / 2006 / Chronic vitamin D3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons / J Neurosci Res 83:1179~1189
Lin AM / 2005 / Antioxidative effect of vitamin D3 on zinc-induced oxidative stress in CNS / Ann N Y Acad Sci 1053:319~329
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