지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제14권 제3호
- 발행연도
- 2015.1
- 수록면
- 123 - 127 (5page)
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초록· 키워드
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Background and PurposeHigh-sensitivity C-reactive protein (hs-CRP) is the most widely studied biomarker of systemic inflammation. Its level has been reported to be associated with cognitive impairment. While dementia and cognitive impairment are common non-motor symptoms in advanced idiopathic Parkinson’s disease (PD), the clinical value of hs-CRP for predicting dementia in PD patients remains unclear. Therefore, the objective of this study was to clarify the relationship between hs-CRP levels and the development or progression of dementia in PD through evaluating hs-CRP levels in PD patients with or without dementia.
MethodsA total of 112 PD patients without dementia (PD-D), 103 PD patients with dementia (PD+D), and 94 healthy controls were used in this study. The levels of hs-CRP and cognitive function were analyzed among these three groups.
ResultsThe mean serum hs-CRP levels in PD-D and PD+D were 1.76±3.62 mg/dL and 1.44±2.78 mg/dL, respectively, which were significantly (p=0.02) higher than that (vs. 0.41±1.06 mg/dL) in healthy controls. However, the levels of hs-CRP were not significantly (p>0.05) different between PD-D and PD+D.
ConclusionsOur results suggest that neuro-inflammation plays a role in the pathogenesis of PD. However, it does not significantly contribute to the development or the progression of dementia in PD patients.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
American Psychiatric Association / 2000 / Diagnostic and statistical manualtext revision (DSM-IV-TRim, 2000) / American Psychiatric Association
Anang JB / 2014 / Predictors of dementia in Parkinson disease: a prospective cohort study / Neurology 83 : 1253 ~ 1260
Chen H / 2003 / Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease / Arch Neurol 60 : 1059 ~ 1064
Di Napoli M / 2012 / C-reactive protein in intracerebral hemorrhage: time course, tissue localization, and prognosis / Neurology 79 : 690 ~ 699
Engelhart MJ / 2004 / Inflammatory proteins in plasma and the risk of dementia: the rotterdam study / Arch Neurol 61 : 668 ~ 672
Anang JB / 2014 / Predictors of dementia in Parkinson disease: a prospective cohort study / Neurology 83 : 1253 ~ 1260
Chen H / 2003 / Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease / Arch Neurol 60 : 1059 ~ 1064
Di Napoli M / 2012 / C-reactive protein in intracerebral hemorrhage: time course, tissue localization, and prognosis / Neurology 79 : 690 ~ 699
Engelhart MJ / 2004 / Inflammatory proteins in plasma and the risk of dementia: the rotterdam study / Arch Neurol 61 : 668 ~ 672
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