지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 122 - 128 (7page)
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초록· 키워드
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Objectives: Cornu cervi pantotrichum (CCP) has been widely used in Korean and China, as an anti-fatigue, anti-aging, and tonic agent to enhance the functions of the reproductive and the immune systems. Because CCP has various growth factors that play important roles in the development of hair follicles, we examined whether CCP pharmacopuncture solution (CCPPS) was capable of promoting hair growth in an animal model.
Methods: One day after hair depilation, CCPPS were topically applied to the dorsal skin of C57BL/6 mice once a day for 15 days. Hair growth activity was evaluated by using macro- and microscopic observations.
Dorsal skin tissues were stained with hematoxylin and eosin. Expressions of bromodeoxyuridine (BrdU), proliferating cell nuclear antigen (PCNA), and fibroblast growth factor (FGF)-7 were examined by using immunohistochemical staining. A reverse transcription polymerase chain reaction (RT-PCR) analysis was also conducted to measure the messenger RNA (mRNA) expression of FGF-7.
Results: CCPPS induced more active hair growth than normal saline. Histologic analysis showed enlargement of the dermal papilla, elongation of the hair shaft, and expansion of hair thickness in CCPPS treated mice, indicating that CCPPS effectively induced the development of anagen. CCPPS treatment markedly increased the expressions of BrdU and PCNA in the hair follicles of C57BL/6 mice. In addition, CCPPS up regulated the expression of FGF-7, which plays an important role in the development of hair follicles.
Conclusion: These results reveal that CCPPS facilitates hair re-growth by proliferation of hair follicular cells and up-regulation of FGF-7 and suggest that CCPPS can potentially be applied as an alternative treatment for patients with alopecia.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Kazantseva A / 2006 / Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH / Science 314(5801):982~985
Kaufman KD / 2002 / Androgens and alopecia / Mol Cell Endocrinol 198(1-2):89~95
Hadshiew IM / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123(3):455~457
Peters EM / 2006 / Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control / Exp Dermatol 15(1):1~13
Lixin Wang / 2011 / CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice / PLoS ONE 16(2):e16377
Kaufman KD / 2002 / Androgens and alopecia / Mol Cell Endocrinol 198(1-2):89~95
Hadshiew IM / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123(3):455~457
Peters EM / 2006 / Hair growth inhibition by psychoemotional stress: a mouse model for neural mechanisms in hair growth control / Exp Dermatol 15(1):1~13
Lixin Wang / 2011 / CRF Receptor Antagonist Astressin-B Reverses and Prevents Alopecia in CRF Over-Expressing Mice / PLoS ONE 16(2):e16377
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