지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 81 - 90 (10page)
이용수
초록· 키워드
오류제보하기
Objectives : Angelicae Gigantis Radix has been known traditional medicine with antimicrobial activities and it has been widely used for treatment of blood and inflammatory diseases. In the present study, some studies examined anti-inflammation effects of Angelicae Gigantis Radix but they usually were performed by ethanol extracted Angelicae Gigantis Radix pharmacopuncture. So We investigated the inhibitory effects of Angelicae Gigantis Radix pharmacopuncture by hot water and ethanol extract on Nitric oxide(NO) and Prostaglandin E2(PGE2) production in lipopolysaccharide(LPS)induced macrophage cell.
Methods : Angelicae Gigantis Radix was extracted by ethanol and hot water. Cell viability was determined by MTT assay. To evaluate anti-inflammation effects of Angelicae Gigantis Radix pharmacopuncture,we examined NO and PGE2 production in LPS induced macrophages. The concentrations of NO and PGE2 were measured by Griess assay and Enzyme Immuno-Assay.
Results :1) The MTT assay demonstrated that cytotoxic effect of Angelicae Gigantis Radix pharmacopuncture by hot water extract and ethanol extract in RAW 264.7 macrophage cells were not appeared.
2) Angelicae Gigantis Radix pharmacopuncture by ethanol extract and hot water extract inhibited NO production in LPS induced macrophages significantly.
3) Angelicae Gigantis Radix pharmacopuncture by ethanol extract tended to inhibiting PGE2 production in LPS induced macrophages. And Angelicae Gigantis Radix pharmacopuncture by hot water extract inhibited LPS induced production of PGE2 in RAW 264.7 macrophage cells significantly.
Conclusions : This study suggests that Angelicae Gigantis Radix pharmacopuncture may have an anti-inflammatory property through the inhibition of NO and PGE2 production in LPS induced macrophages. It may have a therapeutic potential for the treatment of various inflammatory diseases.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
[학술지(
/ 2000 / The Role of Spinal NO on the Mechanical Allodynia in the Inflammatioa Model by Freund`s Complete Adjuvant / The Journal of the Korean Society of Anesthesiologists 3
/ 2007 / Inhibitory Effect of Angelica gigas Nakai Extract on Nitric Oxide Production in RAW 264.7 Cells / The Journal of Korean Oriental Medicine Society 28 (2) : 138 ~ 148
Abul K.Abbas / 2006 / Cellular and Molecular Immunology. 6th edition / Saunders Elsevier : 75 ~ 97
Bae SC / 1997 / Nitric oxide(NO) in Inflammatory Arthritis / The Journal of Korean Orienatal Internal Medicine Society 52 (1) : 32 ~ 41
/ 2000 / The Role of Spinal NO on the Mechanical Allodynia in the Inflammatioa Model by Freund`s Complete Adjuvant / The Journal of the Korean Society of Anesthesiologists 3
/ 2007 / Inhibitory Effect of Angelica gigas Nakai Extract on Nitric Oxide Production in RAW 264.7 Cells / The Journal of Korean Oriental Medicine Society 28 (2) : 138 ~ 148
Abul K.Abbas / 2006 / Cellular and Molecular Immunology. 6th edition / Saunders Elsevier : 75 ~ 97
Bae SC / 1997 / Nitric oxide(NO) in Inflammatory Arthritis / The Journal of Korean Orienatal Internal Medicine Society 52 (1) : 32 ~ 41
이 논문의 저자 정보
최근 본 자료
댓글(0)
0