지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 103 - 110 (8page)
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Backgrounds: Many reports have proposed a significant role for vitamin D in immune mediated disease. This study analyzed the lymphocyte subsets according to serum 25(OH) vitamin D levels in postmenopausal women to determine the potential effect of vitamin D on immune-mediated disease.
Methods: We enrolled 31 postmenopausal women who underwent health checkup in a university hospital. Peripheral blood samples were taken for the investigation of the levels of T, B, and natural killer (NK) cells and the, proportion of CD3+, CD4+ ,CD8+, Th1, Th2, Th17 and Treg subsets of T lymphocyte in the morning after overnight fast. We also measured serum 25(OH) Vitamin D and evaluated the relationship between vitamin D levels and lymphocyte subpopulations.
Results: The subjects were divided into three groups according to serum vitamin D levels. There was no significant correlation between the level of vitamin D and the percentages of three lymphocyte subtypes. The proportion of CD4+ T cell (P for trend 0.024) and the CD4+/CD8+ T cell ratio(P for trend 0.000) was declined across increasing tertiles of vitamin D levels. The proportion of CD8+T cell was increased with increasing of tertiles of vitamin D levels (P for trend 0.004). And the results showed that the CD4+/CD8+ T cell ratio differed significantly between the groups with lowest and the middle vitamin D levels and between the groups with lowest and the highest.
Conclusions: Serum vitamin D levels in postmenopausal women are associated with changes in the peripheral T cell compartment. These results provide insight into the immunomodulatory properties of vitamin D andthe possible beneficial associations between vitamin Dand immune-mediated disease.
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참고문헌 (25)
참고문헌 신청
Bikle D. / 2009 / Nonclassic actions of vitamin D / The Journal of clinical endocrinology and metabolism 94 : 26 ~ 34
Boonstra A / 2001 / 1alpha, 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells / Journal of Immunology 167 : 4974 ~ 49
Garcia de Tena J / 2011 / Vitamin D insufficiency / N Engl J Med 364 (14) : 1378 ~
Gatenby P / 2013 / Vitamin D deficiency and risk for rheumatic diseases: an update / Curr Opin Rheumatol 25 : 184 ~ 191
Heine G / 2010 / Vitamin D deficiency in patients with cutaneous lupus erythematosus is prevalent throughout the year / Br J Dermatol 163 : 863 ~ 865
Boonstra A / 2001 / 1alpha, 25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells / Journal of Immunology 167 : 4974 ~ 49
Garcia de Tena J / 2011 / Vitamin D insufficiency / N Engl J Med 364 (14) : 1378 ~
Gatenby P / 2013 / Vitamin D deficiency and risk for rheumatic diseases: an update / Curr Opin Rheumatol 25 : 184 ~ 191
Heine G / 2010 / Vitamin D deficiency in patients with cutaneous lupus erythematosus is prevalent throughout the year / Br J Dermatol 163 : 863 ~ 865
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