지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 131 - 136 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Nephrocalcinosis (NC) is frequently observed in premature infants. Small-scale studies have suggested that NC adversely affects renal function; however, the etiologic factors are still unclear. This prospective observational study aimed to iden- tify the factors that influence the development of NC, through urine analysis.
Methods: In total, 99 preterm infants (gestational age <34 weeks) diagnosed with NC in the neonatal intensive care unit (NICU) from October 2010 to March 2014 were evaluated. Data regarding perinatal characteristics, respiratory support, total parente- ral nutrition (TPN), and use of nephrotoxic drugs were analyzed. After an ultrasono- graphic diagnosis of NC, the infants were subjected to biweekly urine tests along with ultrasonographic follow-ups until the resolution of NC, in the outpatient department.
Results: NC was diagnosed in 23% (99/432) of the preterm infants admitted to the NICU. Their median gestational age and birth weight were 28+3 (range:23+5-35+2) weeks and 1,120 (range: 560-1,950) g, respectively. NC was diagnosed an average of 26.4±2.8 (range: 2-82) days after birth, and the corrected gestational age at that time was 32.4± 2.0 weeks. Preterm infants with NC had hyperoxaluria (oxalate/Cr=4.1 [oxalate/Cr< 0.3]), and low urinary citrate levels (citrate/Cr=0.03 [citrate/Cr>0.51]). The follow-up rate was 52% (27/52) and symptoms in none of the infants had progressed to nephro- lithiasis. In the infants that were followed up, NC was resolved at a mean age of 7.7 (range: 2-32) months.
Conclusion: Our results suggest that hyperoxaluria is a significant risk factor for the development of NC.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Hufnagle KG / 1982 / Renal calcifications: a complication of long-term furosemide therapy in preterm infants / Pediatrics 70:360~363
Schell-Feith EA / 2010 / Nephrocalcinosis in preterm neonates / Pediatr Nephrol 25:221~230
Hein G / 2004 / Development of nephrocalcinosis in very low birth weight infants / Pediatr Nephrol 19:616~620
Downing GJ / 1992 / Kidney function in very low birth weight infants with furosemide-related renal calcifications at ages 1 to 2 years / J Pediatr 120:599~604
Kist-van Holthe JE / 2007 / Is nephrocalcinosis in preterm neonates harmful for long-term blood pressure and renal function? / Pediatrics 119:468~475
Schell-Feith EA / 2010 / Nephrocalcinosis in preterm neonates / Pediatr Nephrol 25:221~230
Hein G / 2004 / Development of nephrocalcinosis in very low birth weight infants / Pediatr Nephrol 19:616~620
Downing GJ / 1992 / Kidney function in very low birth weight infants with furosemide-related renal calcifications at ages 1 to 2 years / J Pediatr 120:599~604
Kist-van Holthe JE / 2007 / Is nephrocalcinosis in preterm neonates harmful for long-term blood pressure and renal function? / Pediatrics 119:468~475
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