지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 102 - 108 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: Congenital diaphragmatic hernia (CDH) is rare but potentially fatal. The overall outcome is highly variable. This study aimed to identify a simple and dynamic parameter that helps predict the mortality of CDH patients in real time, without invasive tests. Methods: We conducted a retrospective chart review of 59 CDH cases. Maternal and fetal information included the gestational age at diagnosis, site of defect, presence of liver herniation, and lung-to-head ratio (LHR) at 20 to 29 weeks of gestational age. Information regarding postnatal treatment, including the number of days until surgery, the need for inhaled nitric oxide (iNO), the need for extracorporeal membrane oxygenation (ECMO), and survival, was collected. The highest respiratory severity score (RSS) within 24 hours after birth was also calculated. Results: Statistical analysis showed that a younger gestational age at the initial diagnosis (P<0.001), a lower LHR (P=0.001), and the presence of liver herniation (P= 0.003) were prenatal risk factors for CDH mortality. The RSS and use of iNO and ECMO were significant factors affecting survival. In the multivariate analysis, the only remaining significant risk factor was the highest preoperative RSS within 24 hours after birth (P=0.002). The area under the receiver operating characteristic curve was 0.9375, with a sensitivity of 91.67% and specificity of 83.87% at the RSS cut-off value of 5.2. The positive and negative predictive values were 82.14% and 92.86%, respectively. Conclusion: Using the RSS as a prognostic predictor with simple calculations will help clinicians plan CDH management.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Barriere F / 2018 / One-year outcome for congenital diaphragmatic hernia: results from the French National Register / J Pediatr 193:204~210
Brindle ME / 2014 / A clinical prediction rule for the severity of congenital diaphragmatic hernias in newborns / Pediatrics 134:e413~e419
Schultz CM / 2007 / Congenital diaphragmatic hernia: a simplified postnatal predictor of outcome / J Pediatr Surg 42:510~516
van den Hout L / 2010 / Risk factors for chronic lung disease and mortality in newborns with congenital diaphragmatic hernia / Neonatology 98:370~380
Akinkuotu AC / 2016 / Risk-stratification of severity for infants with CDH: prenatal versus postnatal predictors of outcome / J Pediatr Surg 51:44~48
Brindle ME / 2014 / A clinical prediction rule for the severity of congenital diaphragmatic hernias in newborns / Pediatrics 134:e413~e419
Schultz CM / 2007 / Congenital diaphragmatic hernia: a simplified postnatal predictor of outcome / J Pediatr Surg 42:510~516
van den Hout L / 2010 / Risk factors for chronic lung disease and mortality in newborns with congenital diaphragmatic hernia / Neonatology 98:370~380
Akinkuotu AC / 2016 / Risk-stratification of severity for infants with CDH: prenatal versus postnatal predictors of outcome / J Pediatr Surg 51:44~48
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