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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 74 - 78 (5page)
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Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpes virus 1 and 2 (HHV-1 and HHV-2), are two members of the herpes virus family, herpes viridae, which infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. Herpes Simplex can be spread through contact with saliva, such as sharing drinks. HSV-2 is one of the most prevalent sexually transmitted infections worldwide. In addition to recurrent genital ulcers, HSV-2 causes neonatal herpes, and is associated with a 3-fold increased risk for HIV acquisition. Many HSV-2 vaccines have been studied in animal models, however, few have reached clinical trials, and those that have been tested in humans were not consistently effective. Here, I review HSV-2 pathogenesis, with a focus on novel understanding of mucosal immunobiology of HSV-2, and vaccine efforts to date, in an attempt to stimulate thinking about future directions for development of effective prophylactic and therapeutic HSV-2 vaccines.
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참고문헌 (23)
참고문헌 신청
Awasthi S / 2009 / Immunization with HSV-1 glycoprotein C prevents immune evasion from complement and enhances the efficacy of an HSV-1 glycoprotein D subunit vaccine / Vacc
Belshe RB / 2012 / Efficacy results of a trial of a herpes simplex vaccine / N Engl J Med 366 : 34 ~ 43
Bourne N / 2003 / Herpes simplex virus(HSV)type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs / J Infect Dis 187 : 5
Corey L / 2007 / An update on short-course episodic and prevention therapies for herpes genitalis / Herpes 14 (Suppl 1) : 5A ~ 11A
Courreges MC / 2006 / Preparation of apoptotic tumor cells with replicationincompetent HSV augments the efficacy of dendritic cell vaccines / Cancer Gene Ther 13 : 182 ~ 193
Belshe RB / 2012 / Efficacy results of a trial of a herpes simplex vaccine / N Engl J Med 366 : 34 ~ 43
Bourne N / 2003 / Herpes simplex virus(HSV)type 2 glycoprotein D subunit vaccines and protection against genital HSV-1 or HSV-2 disease in guinea pigs / J Infect Dis 187 : 5
Corey L / 2007 / An update on short-course episodic and prevention therapies for herpes genitalis / Herpes 14 (Suppl 1) : 5A ~ 11A
Courreges MC / 2006 / Preparation of apoptotic tumor cells with replicationincompetent HSV augments the efficacy of dendritic cell vaccines / Cancer Gene Ther 13 : 182 ~ 193
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