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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 51 - 57 (7page)
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Purpose: The effects of Lactobacillus fermentation extract (LFE) on cystitis induced by Escherichia coli lipopolysaccharide (LPS) in the mouse bladder were investigated by pathological analyses and measurement of the levels of tumor necrosis factor-alpha (TNF-) and interleukin-18 (IL-18).Materials and Methods: LFE was administered orally (5 g/L) to mice for 10 days after which the study group (n=12) received transurethral injection of 5 g/L LPS. The bladder tissue was then harvested after 24 hours and subjected to hematoxylin and eosin staining. A semi-quantitative score was used to evaluate inflammation (bladder inflammation index, BII). TNF- immunohistochemical staining and multiplex cytokine assays were also performed. TNF- and IL-18 levels were determined. The results were compared with those of the control group (n=12).Results: The BII in the control and study groups was 2.7±0.5 and 1.1±0.7, respectively, with the control group scores differing significantly from the study group scores (p<0.001). TNF- immunohistochemical staining results were similar. The TNF- levels determined by the multiplex cytokine assay were 2.82±1.35 pg/mg and 1.55±0.56 pg/mg for the control and study groups, respectively, and the difference between these groups was statistically significant (p=0.007).Conclusions: Oral administration of LFE appears to have a preventive effect against the inflammatory responses and TNF- expression induced by transurethral instillation of LPS in the mouse bladder. Further studies are required to determine the clinical application of this finding.
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참고문헌 (28)
참고문헌 신청
배현주 / 2011 / 지역사회 단순 요로감염에서의 항생제 내성 및 최신 치료 / 대한내과학회지 81(6):685~689
김태형 / 2012 / 단순방광염의 경험치료제의 선택: 더 이상 가능하지 않은 무임승차 / Infection and Chemotherapy 44(4):323~327
Barrons R / 2008 / Use of Lactobacillus probiotics for bacterial genitourinary infections in women: a review / Clin Ther 30:453~468
유광호 / 2007 / 최근 요로감염증의 주요 원인균과 항생제 감수성에 관한 고찰 / Investigative and Clinical Urology 48(6):638~645
김희연 / 2009 / 중환자 집중 치료실에서 발생하는 요로감염의 주요 원인균과 항생제 감수성의 변화 / Investigative and Clinical Urology 50(11):1108~1113
김태형 / 2012 / 단순방광염의 경험치료제의 선택: 더 이상 가능하지 않은 무임승차 / Infection and Chemotherapy 44(4):323~327
Barrons R / 2008 / Use of Lactobacillus probiotics for bacterial genitourinary infections in women: a review / Clin Ther 30:453~468
유광호 / 2007 / 최근 요로감염증의 주요 원인균과 항생제 감수성에 관한 고찰 / Investigative and Clinical Urology 48(6):638~645
김희연 / 2009 / 중환자 집중 치료실에서 발생하는 요로감염의 주요 원인균과 항생제 감수성의 변화 / Investigative and Clinical Urology 50(11):1108~1113
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