Carcinoma Showing Thymus Like Differentiation (CASTLE) 1예 대한 경험

김종현; 박근명; 김세중; 조영업; 주영채

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자료유형: 학술저널

저자정보: 김종현 박근명 김세중 조영업 주영채

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제11권 제4호

발행연도: 2011.1

수록면: 292 - 296 (5page)

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Carcinoma showing thymus-like differentiation (CASTLE) is a very rare malignant neoplasm of the thyroid, which resembles lymphoepithelioma or squamous cell carcinoma of the thymus. It originates from ectopic thymic tissue or remnants of the branchial pouches. We recently experienced a case of CASTLE in the thyroid gland of a 65-year-old woman. The patient presented with a non-tender mass in the right thyroid gland and dyspnea and coughing upon bending. The patient was diagnosed with ‘cystic change of adenomatous goiter' of the thyroid by fine needle aspiration cytology. Right thyroidectomy was performed because of nodular hyperplasia on frozen biopsy. Histologic examination of the resected tumor showed that the tumor was lobulated and expansive growth pattern, with fibrous septa dividing the tumor and infiltrated by lymphocytes and plasma cells. Tumor cells possessed oval, large vesicular nuclei and prominent nucleoli, and the immunohistochemical staining was positive for CD5. The patient was diagnosed with thyroid CASTLE. We performed complete thyroidectomy. There has been no local regional recurrence. (Korean J Endocrine Surg 2011;11:292-296)

#흉선 #갑상선샘 #갑상선절제술 #Thymus #Thyroid gland #Thyroidectomy

참고문헌 (13)

참고문헌 신청

Ahuja AT / 1998 / Carcinoma showing thymic like differentiation (CASTLE tumor) / AJNR Am J Neuroradiol 19 : 1225 ~ 1228

Berezowski K / 1996 / CD5 immunoreactivity of epithelial cells in thymic carcinoma and CASTLE using paraffinembedded tissue / Am J Clin Pathol 106 : 483 ~ 486

Chan JK / 1991 / Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept / Hum Pathol 22 : 349 ~ 367

Da J / 1999 / Thyroid squamous-cell carcinoma showing thymus-like element (CASTLE): a report of eight cases / Zhonghua Zhong Liu Za Zhi 21 : 303 ~ 304

Damiani S / 1991 / Carcinoma of the thyroid showing thymoma-like features / Virchows Arch A Pathol Anat Histopathol 418 : 463 ~ 466