갑상선 유두암에서 BRAFV600E 돌연변이와 연관된 임상병리학적 인자 및 초음파 소견과의 연관성

최향숙; 김광민; 박준범; 배금석; 강성준

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자료유형: 학술저널

저자정보: 최향숙 김광민 박준범 배금석 강성준

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제12권 제1호

발행연도: 2012.1

수록면: 16 - 20 (5page)

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Purpose: This study evaluated the association of the BRAFV600E mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma. Methods: Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011. Results: Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAFV600E mutation. Neither age nor sex were associated with the BRAFV600E mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAFV600E mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation. Conclusion: As debate remains about the association between the BRAFV600E mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed.

#BRAFV600E 돌연변이 #임상 병리학적 인자 #초음파 소견 #BRAFV600E mutation #Clinicopathologic factors #Ultrasonographic characteristics

참고문헌 (24)

참고문헌 신청

Chung KW / 2006 / Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-pre

Costa AM / 2008 / BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma / Clin Endocrinol (Oxf) 68 : 618 ~ 634

Cushing SL / 2004 / Prognostic factors in well-differentiated thyroid carcinoma / Laryngoscope 114 : 2110 ~ 2115

Frasca F / 2008 / BRAF (V600E) mutation and the biology of papillary thyroid cancer / Endocr Relat Cancer 15 : 191 ~ 205

Guan H / 2009 / Association of high iodine intake with the T1799A BRAF mutation in papillary thyroid cancer / J Clin Endocrinol Metab 94 : 1612 ~ 1617