갑상선유두암에서 p53과 Cyclin D1의 발현이 가지는 예후인자로서의 의미

석재연; 정동해; 정유승; 류정원; 이영돈

추천

검색

자료유형: 학술저널

저자정보: 석재연 정동해 정유승 류정원 이영돈

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제15권 제2호

발행연도: 2015.1

수록면: 25 - 33 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: P53 and cyclin D1 have been evaluated as a prognostic marker in papillary thyroid carcinoma (PTC). However, the relationship between p53/cyclin D1 and PTC prognosis has not yet been confirmed. Therefore, we investigated the relationship between p53/cyclin D1 and PTC prognostic factors.Methods: 919 patients with PTC were enrolled. Immunohistochemistry slides were reviewed for p53 and cyclin D1 immunoreactivity. Patients were classified into two groups according to the p53 and cyclin D1 grade: negative for ≤5% and positive for ＞5%. Medical records were reviewed to evaluate the prognostic factors, lymph node metastatic ratio (LNMR), and MACIS score. We analyzed patients based on p53/cyclin D1(−/−), p53/cyclin D1(−/＋), p53/cyclin D1(＋/−), p53/cyclin D1(＋/＋) separately for evaluation of independent effect of p53 and cyclin D1.Results: Mean age of the patients was 49.73 years (range 15∼87), and tumor size was 1.19 cm (range 0.1∼5.0). P53 was positive in 809 (88.0%) and cyclin D1 was positive in 748 (81.4%). Positivity of p53 and cyclin D1 were correlated (r=0.448). There was no statistical significance in MACIS score. Positivity of p53 and cyclin D1 were related with larger tumor size, older age, early T stage, more tumor capsulation, and female. LNMR was higher in p53/cyclin D1(＋/−) than p53/cyclin D1(−/−) (P=0.036), p53/cyclin D1(−/＋) than p53/cyclin D1(−/−) (P=0.034), and p53/cyclin D1(＋/＋) than p53/cyclin D1(−/−) (P=0.007). Conclusion: There was no consistent relationship between p53/cyclin D1 and worse prognostic factors of PTC. However, LNMR was higher in p53(＋) and cyclin D1(＋) cases independently, much more in p53/cyclin D1(＋/＋) than p53/cyclin D1(−/−).

#갑상선유두암 #예후 #림프절 전이율 #p53 #Cyclin D1 #Papillary thyroid carcinoma #p53 #Cyclin D1 #Prognosis #Lymph node metasta-tic ratio

참고문헌 (24)

참고문헌 신청

[학술지(정기간

Balta AZ / 2012 / Prognostic value of oncoprotein expressions in thyroid papillary carcinoma / Med Oncol 29 : 734 ~ 741

Basolo F / 2000 / Cyclin D1 overexpression in thyroid carcinomas: relation with clinico-pathological parameters, retinoblastoma gene product, and Ki67 labeling index / Thyro

Hay ID / 1993 / Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779patients surgically treated at one

Ji WB / 2007 / The significance of bcl-2 and p53 expressions in the papillary thyroid cancer / Korean J Endocr Surg 7 : 231 ~ 236

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!