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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 183 - 190 (8page)
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Purpose: This study evaluated the risk factors for distant metastasis in patients with minimally invasive follicular thyroid carcinoma (MIFTC) and compared distant metastasis-free survival (DMFS) rates between the groups divided based on the number of involved risk factors. Methods: Patients were divided into 4 groups based on the number of involved risk factors; group 0 with no risk factor, group 1 with any one risk factor, group 2 with any 2 risk factors, and group 3 with all risk factors. Results: The 195 patients were enrolled in this study. Distant metastasis was detected in 15 patients (7.7%). In the multivariate analysis, age ≥ 45 years (hazard ratio [HR]=5.95; 95% confidence interval [CI]=1.44–24.55; P=0.014), primary tumor size >4.0 cm (HR=4.79; 95% CI=1.18–19.33; P=0.028), and extensive vascular invasion with ≥4 foci (HR=19.63; 95% CI=5.18–74.39; P<0.001) were identified as independent risk factors for distant metastasis. Group 1 tended to have poorer DMFS rates as compared with group 0, but there was no significant difference (P=0.069). DMFS rates of group 2 and 3 were significantly poorer than those of group 1 (P<0.001 and <0.001, respectively). DMFS rates of group 3 were also significantly poorer than those of group 2 (P=0.004). Conclusion: MIFTC patients with no or only one distant metastasis-related risk factor may become candidates for close observation without additional treatments with respect toDMFS rates.
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참고문헌 (15)
참고문헌 신청
DeLellis RA / 2004 / Pathology and Genetics of Tumours of Endocrine Organs / IARC Press
Asari R / 2009 / Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial / Ann Surg 249:1023~1031
Ban EJ / 2012 / Follicular thyroid cancer: minimally invasive tumours can give rise to metastases / ANZ J Surg 82:136~139
Goffredo P / 2013 / Can minimally invasive follicular thyroid cancer be approached as a benign lesion?: a population-level analysis of survival among 1,200 patients / Ann Surg Oncol 20:767~772
Huang CC / 2011 / Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas / Surg Oncol 20:1~6
Asari R / 2009 / Follicular thyroid carcinoma in an iodine-replete endemic goiter region: a prospectively collected, retrospectively analyzed clinical trial / Ann Surg 249:1023~1031
Ban EJ / 2012 / Follicular thyroid cancer: minimally invasive tumours can give rise to metastases / ANZ J Surg 82:136~139
Goffredo P / 2013 / Can minimally invasive follicular thyroid cancer be approached as a benign lesion?: a population-level analysis of survival among 1,200 patients / Ann Surg Oncol 20:767~772
Huang CC / 2011 / Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas / Surg Oncol 20:1~6
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