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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Pharmacological interventions are critical in dementia treatment to prevent disease progression. In this review, we aim to summarize and discuss about the current developments and recommendations in the pharmacological treatment of dementia. Cholinesterase inhibitors have demonstrated efficacy for Alzheimer’s disease, mixed pathology with vascular dementia and Parkinson’s disease dementia. The comparison study revealed no difference between each cholinesterase inhibitors. A high incidence of side effects of cholinesterase inhibitors could lower compliance. In this case, changing to the other drug or trying a transdermal type could be the solution. Memantine, a N-methyl-D-aspartate receptor antagonist, has proven to improve function at moderate to severe dementia and for dementia with Lewy body. But there are still in- sufficient evidences for the combination of a cholinesterase inhibitors and memantine. Discontinuing medicine in moderate to severe dementia may lead to worsening of cognitive function. For this reason, improving patients’ compliance is im- portant and for drug selection we should consider the type of dementia, severity of cognitive impairment and side effects of each medicine. Noncognitive symptoms, behavioral and psychological symptoms of dementia (BPSD) are common and can dominate disease presentation. For depression, selective serotonin reuptake inhibitors could be effective. Atypical antipsychotics could be used for other neuropsychological symptoms such as agitation, aggression, delusions and hallucinations.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
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Ballard C / 2008 / Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: The vantage study / Curr Med Res Opin 24 : 2561 ~ 2
Ballard C / 2009 / The dementia antipsychotic withdrawal trial (dart-ad): Long-term follow-up of a randomised placebo-controlled trial / Lancet Neurol 8 : 151 ~ 157
Banerjee S / 2011 / Sertraline or mirtazapine for depression in dementia (hta-sadd):A randomised, multicentre, double-blind, placebo-controlled trial / Lancet 378 : 403 ~ 41
Black S / 2003 / Efficacy and tolerability of donepezil in vascular dementia:Positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinica
Ballard C / 2008 / Efficacy, safety and tolerability of rivastigmine capsules in patients with probable vascular dementia: The vantage study / Curr Med Res Opin 24 : 2561 ~ 2
Ballard C / 2009 / The dementia antipsychotic withdrawal trial (dart-ad): Long-term follow-up of a randomised placebo-controlled trial / Lancet Neurol 8 : 151 ~ 157
Banerjee S / 2011 / Sertraline or mirtazapine for depression in dementia (hta-sadd):A randomised, multicentre, double-blind, placebo-controlled trial / Lancet 378 : 403 ~ 41
Black S / 2003 / Efficacy and tolerability of donepezil in vascular dementia:Positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinica
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