지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 30 - 38 (9page)
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초록· 키워드
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Background and Objectives: The BRAF^(V600E) mutation has been regarded as the leading cause of papillary thyroid cancer (PTC). However, the multi-step carcinogenic process induced by BRAF^(V600E) has been remained to be elucidated in thyroid gland. In this study, to investigate staged development of papillary thyroid carcinoma, we observed the histo-pathological findings of thyroid gland from BRAF^(V600E) transgenic mice with a period of 60 weeks. Materials and Methods: We histologically inspected 3, 9, 20, 27, 39, 44, 48 and 60 week old BRAF^(V600E) transgenic mice derived from FVB/N background mice with a bovine thyroglobulin promoter which are providing thyroid specific BRAF^(V600E) expression. Results: Thyroid glands from 3 and 9 week old BRAF^(V600E)transgenic mice were enlarged and showed abnormal histologic feature such as distorted follicular architectures. The 20 and 27 week old BRAF^(V600E) transgenic mice showed irregularly enlarged thyroid gland sprouting out above the carotid arteries. Thyroid gland derived from 39 week old mice showed reduced formation of intact follicular structure and increased solid area. Thyroid glands were entirely replaced by firm tumor mass composed of poorly differentiated cell at 44 weeks. Interestingly, we could observe tracheal invasion, surrounding muscle invasion in thyroid gland from 48 week old mice and detect lung metastasis in 60 week old mice. Conclusion: Thyroid specific expression of BRAF^(V600E) induced staged development of thyroid cancer. This finding may support that BRAF^(V600E)have a role in entire carcinogenic process such as tumor initiation, development and progression.
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참고문헌 (21)
참고문헌 신청
Cantwell-Dorris ER / 2011 / BRAFV600E: Implications for carcinogenesis and molecular therapy / Mol Cancer Ther 10 : 385 ~ 394
Dankort D / 2007 / A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors / Genes Dev 21 : 379 ~ 384
Davies H / 2002 / Mutations of the BRAF gene in human cancer / Nature 417 : 949 ~ 954
Decarlo K / 2010 / Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7--challenging the concept of dysplastic nevi as precursor lesions? / Hum Pathol 41
Dhomen N / 2009 / Oncogenic Braf induces melanocyte senescence and melanoma in mice / Cancer Cell 15 : 294 ~ 303
Dankort D / 2007 / A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors / Genes Dev 21 : 379 ~ 384
Davies H / 2002 / Mutations of the BRAF gene in human cancer / Nature 417 : 949 ~ 954
Decarlo K / 2010 / Oncogenic BRAF-positive dysplastic nevi and the tumor suppressor IGFBP7--challenging the concept of dysplastic nevi as precursor lesions? / Hum Pathol 41
Dhomen N / 2009 / Oncogenic Braf induces melanocyte senescence and melanoma in mice / Cancer Cell 15 : 294 ~ 303
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