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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 210 - 214 (5page)
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초록· 키워드
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Sorafenib, an oral multi-kinase inhibitor, is used for the treatment of patients with radioactive iodine (RAI) refractory differentiated thyroid carcinoma (DTC) with favorable outcomes. Some unusual but fatal adverse effects are known for this drug and tracheoesophageal fistula (TEF) is one of them, which has never been reported in thyroid cancer patients. We present a successfully treated patient who had developed TEF associated with rapid tumor regression during sorafenib treatment for locally advanced papillary thyroid carcinoma (PTC). Sorafenib was discontinued and feeding jejunostomy tube was placed for nutritional support. 3 months later, the TEF had successfully healed and there was no visible fistula track or interval change of the viable tumor during 15 months of follow-up. Identifying patients at high risk for this potential complication and paying special attention when prescribing anti-angiogenics to these patients are crucial to prevent associated morbidity and mortality.
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등록된 정보가 없습니다.
참고문헌 (14)
참고문헌 신청
Hundahl SA / 1998 / A National Cancer Data Base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985-1995 / Cancer 83(12):2638~2648
Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97(5):418~428
Durante C / 2006 / Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy / J Clin Endocrinol Metab 91(8):2892~2899
Brose MS / 2014 / Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial / Lancet 384(9940):319~328
Schutz FA / 2012 / Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors / J Clin Oncol 30(8):871~877
Mazzaferri EL / 1994 / Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer / Am J Med 97(5):418~428
Durante C / 2006 / Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy / J Clin Endocrinol Metab 91(8):2892~2899
Brose MS / 2014 / Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial / Lancet 384(9940):319~328
Schutz FA / 2012 / Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors / J Clin Oncol 30(8):871~877
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