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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 845 - 854 (10page)
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초록· 키워드
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Skin lightening is one of the most important effect of functional cosmetics, especially for the asian women. For this reason, many kinds of inhibitors of melanin synthesis by melanocyte have been developed since a decade ago. Although many kinds of melanogenesis inhibitors such as arbutin, ascorbic acid, extract of Licorice root or Morus alba and niacinamide were recommended as the standard component of the skin whitening cosmetics by Korean Food and Drug Administration, they are not always satisfactory to the many users. Mulberroside A, a main component of extract of Morus alba balk, can be converted into an aglycan named oxyresveratrol having a strong antioxidant and anti-melanogenesis effect using β-glucosidase. However, the glucose hydrolysis process using a soluable β-glucosidase is not suitable to convert Mulberrosie A into oxyresveratrol in a large scale procss because of the low reaction rate and high price. In this work, we developed a bioconversion process of oxyresveratrol production from Morus alba extract using enzyme named Accellerase®, which is an immobilized enzyme on the solid particle, and compared the tyrosinase inhibition effect of the extracts of before and after the bioconversion process. It was found that the inhibition effect of Morus alba extract to the mushroom tyrosinase was greatly increased by the bioconversion process and this effect was synergized when the extract was used with arbutin together.
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참고문헌 (20)
참고문헌 신청
Curto EV / 1999 / Inhibitors of mammalian melanocytes tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors / Biochem. Pharmacol 5
Grove GL / 1991 / Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream / J. Am. Acad. Dermatol 25 : 231 ~ 237
Lee CH / 1996 / investigation of melanin biosynthesis inhibition substance / Kor Soc. Appl. Microbiol. Biotechnol 9 : 32 ~ 32
Maeda K / 2001 / In vivo effectiveness of several whitening cosmetic components in human melanocytes / J. Soc. Cosmet. Chem 56 : 397 ~ 401
Pawelek JM / 1982 / The biosynthesis of mammalian melanin / Am. Sci 70 : 91 ~ 126
Grove GL / 1991 / Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream / J. Am. Acad. Dermatol 25 : 231 ~ 237
Lee CH / 1996 / investigation of melanin biosynthesis inhibition substance / Kor Soc. Appl. Microbiol. Biotechnol 9 : 32 ~ 32
Maeda K / 2001 / In vivo effectiveness of several whitening cosmetic components in human melanocytes / J. Soc. Cosmet. Chem 56 : 397 ~ 401
Pawelek JM / 1982 / The biosynthesis of mammalian melanin / Am. Sci 70 : 91 ~ 126
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