담도암 miRNA 진단 칩을 이용한 분석적 성능 시험

이창희; 이정수; 이재훈; 허지연; 노미숙

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자료유형: 학술저널

저자정보: 이창희 이정수 이재훈 허지연 노미숙

저널정보: 한국보건정보통계학회 보건정보통계학회지 보건정보통계학회지 제41권 제3호

발행연도: 2016.1

수록면: 330 - 335 (6page)

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연구주제

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연구배경

🔬

연구방법

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연구결과

초록· 키워드

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Objectives: This study’s purpose was to analyze the analytical performance test of miRNA diagnosis chip for a national project, Development of Multiple Biomarkers Using Integrated Analysis of Next Generation Bio-data, and it was attempted in June 2016. Methods: The evaluation indices of the analytical performance test were reproducibility, repeatability, and specificity. The analytical performance test of miRNA diagnosis chip for bile duct cancer were subjected to analysis of five markers. One same subject had two sessions of the test, and three times were repeated per each session for reproducibility analysis whereas two different subjects had two sessions of the test, and three times were repeated per each session for repeatability analysis. The measured value taken from six times repeated test of patient group of bile duct cancer and the measured value taken from two times repeated test of normal group were compared by using hierarchical clustering analysis in order for specificity analysis. Results: As a result of analysis, all CV (coefficient of variance) values of markers were 10% or below for reproducibility and repeatability, and patient group of bile duct cancer were significantly divided from normal group being completely different groups. Conclusions: Analytical performance test confirmed suitability of miRNA diagnosis chip designed for diagnosing bile duct cancer.

#MicroRNA #Bile duct cancer #Analytical performance #Reproducibility #Repeatability #Specificity

참고문헌 (17)

참고문헌 신청

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Xu X / 2011 / Biomarkers and pharmacogenetics in pancreatic cancer / Highlights from the “2011 ASCO Annual Meeting” 12(4):325~329

Huang H / 2010 / Novel blood biomarkers of pancreatic cancer-associated diabetes mellitus identified by peripheral blood-based gene expression profiles / Am J Gastroenterol 105(7):1661~1669

Hanas JS / 2008 / Biomarker identification in human pancreatic cancer sera / Pancreas 36(1):61~69

Mitchell PS / 2008 / Circulating microRNAs as stable blood-based markers for cancer detection / Proc Natl Acad Sci 105(30):10513~10518

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