지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 1 - 10 (10page)
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초록· 키워드
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To date, efforts to treat autoimmune diseases have primarily focused on the disease symptoms rather than on the cause of the disease. In large part, this is attributed to not knowing the responsible auto-antigens (auto-Ags) for driving the self-reactivity coupled with the poor success of treating autoimmune diseases using oral tolerance methods. Nonetheless, if tolerogenic approaches or methods that stimulate regulatory T (Treg) cells can be devised, these could subdue autoimmune diseases. To forward such efforts, our approach with colonization factor antigen I (CFA/I) fimbriae is to establish bystander immunity to ultimately drive the development of auto-Ag-specific Treg cells. Using an attenuated Salmonella vaccine expressing CFA/I fimbriae, fimbriae-specific Treg cells were induced without compromising the vaccine’s capacity to protect against travelers’diarrhea or salmonellosis. By adapting the vaccine’s anti-inflammatory properties, it was found that it could also dampen experimental inflammatory diseases resembling multiple sclerosis (MS) and rheumatoid arthritis. Because of this bystandereffect, disease-specific Treg cells are eventually induced to resolve disease. Interestingly, this same vaccine could elicit the required Treg cell subset for each disease. For MS-like disease, conventional CD25þ Treg cells are stimulated, but for arthritisCD39þ Treg cells are induced instead. This review article will examine the potential of treating autoimmune diseases without having previous knowledge of the auto-Ag using an innocuous antigen to stimulate Treg cells via the production of transforming growth factor-b and interleukin-10.
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참고문헌 (22)
참고문헌 신청
Anantha RP / 2004 / Evolutionary and functional relationships of colonization factor antigen i and other class 5 adhesive fimbriae of enterotoxigenic Escherichia coli / Infe
Black RE / 1981 / Enterotoxigenic Escherichia coli diarrhoea : acquired immunity and transmission in an endemic area / Bull World Health Organ 59 : 263 ~ 268
Black RE / 1982 / Longitudinal studies of infectious diseases and physical growth of children in rural Bangladesh. II. Incidence of diarrhea and association with known patho
Clements JD / 1978 / Demonstration of shared and unique immunologic determinants in enterotoxins from V. cholerae and E. coli / Infect Immun 22 : 709 ~ 713
Cravioto A / 1988 / Prospective study of diarrhoeal disease in a cohort of rural Mexican children : incidence and isolated pathogens during the first two years of life / Epi
Black RE / 1981 / Enterotoxigenic Escherichia coli diarrhoea : acquired immunity and transmission in an endemic area / Bull World Health Organ 59 : 263 ~ 268
Black RE / 1982 / Longitudinal studies of infectious diseases and physical growth of children in rural Bangladesh. II. Incidence of diarrhea and association with known patho
Clements JD / 1978 / Demonstration of shared and unique immunologic determinants in enterotoxins from V. cholerae and E. coli / Infect Immun 22 : 709 ~ 713
Cravioto A / 1988 / Prospective study of diarrhoeal disease in a cohort of rural Mexican children : incidence and isolated pathogens during the first two years of life / Epi
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