지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 8 (8page)
이용수
초록· 키워드
오류제보하기
Silica nanoparticles (SNPs) are widely used in many scientific and industrial fields despite the lack of proper evaluation of their potential toxicity. This study examined the effects of acute exposure to SNPs, either alone or in conjunction with ovalbumin (OVA), by studying the respiratory systems in exposed mouse models. Three types of SNPs were used: spherical SNPs (S-SNPs), mesoporous SNPs (M-SNPs), and PEGylated SNPs (P-SNPs). In the acute SNP exposure model performed, 6-week-old BALB/c female mice were intranasally inoculated with SNPs for 3 consecutive days. In the OVA/SNPs asthma model, the mice were sensitized two times via the peritoneal route with OVA. Additionally, the mice endured OVA with or without SNP challenges intranasally. Acute SNP exposure induced significant airway inflammation and airway hyper-responsiveness, particularly in the S-SNP group. In OVA/SNPs asthma models, OVA with SNP-treated group showed significant airway inflammation, more than those treated with only OVA and without SNPs. In these models, the P-SNP group induced lower levels of inflammation on airways than both the S-SNP or M-SNP groups. Interleukin (IL)-5, IL-13, IL-1β and interferon-γ levels correlated with airway inflammation in the tested models, without statistical significance. In the mouse models studied, increased airway inflammation was associated with acute SNPs exposure, whether exposed solely to SNPs or SNPs in conjunction with OVA. P-SNPs appear to be relatively safer for clinical use than S-SNPs and M-SNPs, as determined by lower observed toxicity and airway system inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] -
Caplan A. / 1959 / Rheumatoid disease and pneumoconiosis(Caplan’s syndrome) / Proc R Soc Med 52 : 1111 ~ 1113
Carino IS / 2007 / Silica-based mesoporous materials as drug delivery system for methotrexate release / Drug Deliv 14 : 491 ~ 495
Chau E / 2013 / Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro / Nanotoxicology 7 : 1143 ~ 1151
Chen W / 2014 / Induced T cell cytokine production is enhanced by engineered nanoparticles / Nanotoxicology 8 (Suppl 1) : 11 ~ 23
Caplan A. / 1959 / Rheumatoid disease and pneumoconiosis(Caplan’s syndrome) / Proc R Soc Med 52 : 1111 ~ 1113
Carino IS / 2007 / Silica-based mesoporous materials as drug delivery system for methotrexate release / Drug Deliv 14 : 491 ~ 495
Chau E / 2013 / Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro / Nanotoxicology 7 : 1143 ~ 1151
Chen W / 2014 / Induced T cell cytokine production is enhanced by engineered nanoparticles / Nanotoxicology 8 (Suppl 1) : 11 ~ 23
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
심층 신경망을 이용한 SNP 서열에 따른 신경 질환의 분류
대한전자공학회 학술대회
2017 .06
-
LLM 기반 이종 SNP 데이터베이스 통합: 도전 과제와 방향성
한국컴퓨터정보학회 학술발표논문집
2025 .01
-
다이아몬드 FETs에서 전기적 바이어스 방법을 이용한 단일염기 다형성(SNPs) 검출
전자공학회논문지
2015 .03
-
Rapid SNP Detection Assay Using Programmable Molecular Components
한국생물공학회 학술대회
2023 .10
-
Development of Highly Informative Single Nucleotide Polymorphism (SNP) Assay for Genotyping in Hexaploid Wheat (Triticum aestivum L.)
한국생물공학회 학술대회
2021 .10
-
Simple, Accurate and Multiplex SNP Genotyping Method Using Optimized Ligation Reaction Coupled with High Resolution CE-SSCP
한국생물공학회 학술대회
2017 .04
-
Bovine SNP50K BeadChip을 이용한 강원지역 한우의 연관불평형 분석
동물자원연구
2017 .01
-
HNF4α 유전자 내 SNP가 한국 재래계의 성장에 미치는 효과 분석
동물자원연구
2016 .01
-
Toward High Utilization of Heterogeneous Computing Resources in SNP Detection
[ETRI] ETRI Journal
2015 .04
-
질병-유전자-SNP 계층 네트워크에서의 준지도학습을 이용한 치매 관련 핵심 유전자 추천
한국정보과학회 학술발표논문집
2019 .12
-
Silica-Based Advanced Nanoparticles For Treating Ischemic Disease
조직공학과 재생의학
2023 .04
-
Association between the g.7516G>C SNP in the Fatty Acid Binding Protein 4 Gene and Economic Traits in Hanwoo
동물자원연구
2020 .01
-
고밀도 SNP 칩 유전자형 데이터 기계학습 기반 반려견 품종 식별 유전마커 선발
농업생명과학연구
2019 .01
-
Ribosomal Protein S3(RPS3) 유전자 SNP의 버크셔 돼지 육질 형질과의 연관성 분석
농업생명과학연구
2017 .02
-
단일염기다형성 마커를 이용한 백우 품종 식별 방법
한국산학기술학회 논문지
2020 .01
-
Genotyping for Detecting SNPs in Growth Hormone from Nile Tilapia (Oreochromis niloticus)
한국생물공학회 학술대회
2021 .10
-
A Robust SNP Genotyping Method Using Three-Color Fluorescence Labeled Ligase Detection Reaction and High Resolution CE-SSCP
한국생물공학회 학술대회
2016 .10
-
A Highly Multiplex and Sensitive SNP Genotyping Method Using Three Color Fluorescence Labeled Ligase Detection Reaction and High Resolution CE-SSCP
한국생물공학회 학술대회
2015 .10
-
semiconductor sequencing 방식을 사용하여 SNP 기반으로 fetal fraction을 측정하기 위한 연구
한국지능정보시스템학회 학술대회논문집
2017 .08
-
Weight Difference by SNPs Discovered in GHR1 of Nile Tilapia (Oreochromis niloticus)
한국생물공학회 학술대회
2021 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0