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Pentraxin 3 (PTX3) was identified as a marker of the inflammatory response and overexpressed in various tissues and cells related to cardiovascular disease. Honokiol, an active component isolated from the Chinese medicinal herb Magnolia officinalis, was shown to have a variety of pharmacological activities. In the present study, we aimed to investigate the effects of honokiol on palmitic acid (PA)-induced dysfunction of human umbilical vein endothelial cells (HUVECs) and to elucidate potential regulatory mechanisms in this atherosclerotic cell model. Our results showed that PA significantly accelerated the expression of PTX3 in HUVECs through the IκB kinase (IKK)/IκB/nuclear factor-κB (NF-κB) pathway, reduced cell viability, induced cell apoptosis and triggered the inflammatory response. Knockdown of PTX3 supported cell growth and prevented apoptosis by blocking PA-inducted nitric oxide (NO) overproduction. Honokiol significantly suppressed the overexpression of PTX3 in PA-inducted HUVECs by inhibiting IκB phosphorylation and the expression of two NF-κB subunits (p50 and p65) in the IKK/IκB/NF-κB signaling pathway. Furthermore, honokiol reduced endothelial cell injury and apoptosis by regulating the expression of inducible NO synthase and endothelial NO synthase, as well as the generation of NO. Honokiol showed an antiinflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. In summary, honokiol repaired endothelial dysfunction by suppressing PTX3 overexpression in an atherosclerotic cell model. PTX3 may be a potential therapeutic target for atherosclerosis.
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참고문헌 (23)
참고문헌 신청
Alberti L / 2009 / Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors / Atherosclerosis 202 : 455 ~ 460
Black PH. / 2003 / The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic
Eggers KM / 2013 / Clinical and prognostic implications of circulating pentraxin 3 levels in non ST-elevation acute coronary syndrome / Clin Biochem 46 : 1655 ~ 1659
Guo WX / 2008 / Palmitic and linoleic acids impair endothelial progenitor cells by inhibition of Akt/eNOS pathway / Arch Med Res 9 : 434 ~ 442
Hagihara H / 1991 / Role of inflammatory responses in initiation of atherosclerosis : effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal th
Black PH. / 2003 / The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic
Eggers KM / 2013 / Clinical and prognostic implications of circulating pentraxin 3 levels in non ST-elevation acute coronary syndrome / Clin Biochem 46 : 1655 ~ 1659
Guo WX / 2008 / Palmitic and linoleic acids impair endothelial progenitor cells by inhibition of Akt/eNOS pathway / Arch Med Res 9 : 434 ~ 442
Hagihara H / 1991 / Role of inflammatory responses in initiation of atherosclerosis : effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal th
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