지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 12 (12page)
이용수
초록· 키워드
오류제보하기
The hepatic lobule is divided into three zones along the portal-central vein axis. Hepatocytes within each zone exhibit a distinctive gene expression profile that coordinates their metabolic compartmentalization. The zone-dependent heterogeneity of hepatocytes has been hypothesized to result from the differential degree of exposure to oxygen, nutrition and gut-derived toxins.
In addition, the gradient of Wnt signaling that increases towards the central vein seen in rodent models is believed to play a critical role in shaping zonation. Furthermore, hepatic zonation is coupled to the site of the homeostatic renewal of hepatocytes.
Despite its critical role, the regulatory mechanisms that determine the distinctive features of zonation and its relevance to humans are not well understood. The present study first conducted a comprehensive zone-dependent transcriptome analysis of normal human liver using laser capture microdissection. Upstream pathway analysis revealed the signatures of host responses to gut-derived toxins in the periportal zone, while both the canonical Wnt pathway and the xenobiotic response pathway govern the perivenular zone. Furthermore, we found that the hypoxic environment of the perivenular zone promotes Wnt11 expression in hepatocytes, which then regulates unique gene expression via activation of the non-canonical Wnt pathway. In summary, our study reports the comprehensive zonation-dependent transcriptome of the normal human liver. Our analysis revealed that the LPS response pathway shapes the characteristics of periportal hepatocytes. By contrast, the perivenular zone is regulated by a combination of three distinct pathways: the xenobiotic response pathway, canonical Wnt signaling, and hypoxia-induced noncanonical Wnt signaling.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Benhamouche S / 2006 / Apc tumor suppressor gene is the ‘zonation-keeper’ of mouse liver / Dev Cell 10 : 759 ~ 770
Bullard JH / 2010 / Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments / BMC Bioinformatics 11 : 94 ~
Burke ZD / 2009 / Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism / Gastroenterology 136 : 2316 ~ 2324
Clevers H / 2014 / Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control / Science 346 : 1248012 ~
Fang C / 1998 / Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole / Hepatology 27 : 1304 ~ 1310
Bullard JH / 2010 / Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments / BMC Bioinformatics 11 : 94 ~
Burke ZD / 2009 / Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism / Gastroenterology 136 : 2316 ~ 2324
Clevers H / 2014 / Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control / Science 346 : 1248012 ~
Fang C / 1998 / Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole / Hepatology 27 : 1304 ~ 1310
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Wnt5a attenuates the pathogenic effects of the Wnt/β-catenin pathway in human retinal pigment epithelial cells via down-regulating β-catenin and Snail
BMB Reports
2015 .01
-
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Experimental and Molecular Medicine
2020 .02
-
Distinctive Roles of Wnt Signaling in Chondrogenic Differentiation of BMSCs under Coupling of Pressure and Platelet-Rich Fibrin
조직공학과 재생의학
2022 .08
-
Zone-specific hepatotoxicity assessment system by mimicking metabolic liver zonation
한국고분자학회 학술대회 연구논문 초록집
2018 .04
-
Hepatocyte organoids and cell transplantation: What the future holds
Experimental and Molecular Medicine
2021 .10
-
Assembly and Disassembly of the Micropatterned Collagen Sheets Containing Cells for Location‑Based Cellular Function Analysis
BioChip Journal
2021 .01
-
Wnt/β-catenin interacts with the FGF pathway to promote proliferation and regenerative cell proliferation in the zebrafish lateral line neuromast
Experimental and Molecular Medicine
2019 .01
-
Dishevelling Wnt and Hippo
BMB Reports
2018 .01
-
Epigenetic role of nuclear S6K1 in early adipogenesis
BMB Reports
2016 .01
-
Curcumin polymeric micelles suppress the Wnt/Beta-Catenin signaling pathway target colon cancer
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
Curcumin polymeric micelles as inhibitor of the Wnt/beta-catenin signaling pathway target colon cancer
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
Ryk modulates the niche activity of mesenchymal stromal cells by fine-tuning canonical Wnt signaling
Experimental and Molecular Medicine
2020 .01
-
Inhibition of Cyclooxygenase-2 Alters Wnt/b-Catenin Signaling in the Regenerating Tail of Lizard Hemidactylus flaviviridis
조직공학과 재생의학
2017 .01
-
Interacting network of Hippo, Wnt/β-catenin and Notch signaling represses liver tumor formation
BMB Reports
2017 .01
-
PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways
Experimental and Molecular Medicine
2024 .07
-
Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis
Experimental and Molecular Medicine
2019 .01
-
Mechanosensitive β-catenin signaling regulates lymphatic vascular development
BMB Reports
2016 .01
-
miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells
Experimental and Molecular Medicine
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0