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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 46 - 52 (7page)
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Muscarinic receptors play key roles in the control ever, specific physiological functions of each sub-type remain to be determined. In this study, the nonselective cation channel activated by carba-chol (ICCh) was examined in circular smooth mus-cle cels of the guinea pig gastric antrum using patch-clamp technique. 4-DAMP inhibited ICCh dose- dependently with IC50 of 1.10.1 nM (n = 6 ) . G T PγS- induced current, however, was not inhibited by 10 nM 4-DAMP. ICCh was not recorded in pertussis- gastric antrum. ICCh values in response to 10 M Ch at a holding potential of 60 mV were -3032 pA (n=4) and -153 pA (n = 6) in the control and PTX-treated cels, respectively (P＜ 0.01). Sensi-tivities to nanomolar 4-DAMP and PTX suggest the posible involvement of m4 subtype. Using se-quence information obtained from cloned guinea pig muscarinic receptor genes, it is posible to pig brain tissue. Single cel RT-PCR experiments showed that al five subtypes of muscarinic re-ceptor were present in circular smoth muscle cells of the guinea pig gastric antrum. Together with our previous results showing that Go protein is important for activation of ACh-activated NSC channels, our results suggest that ICCh might be activated by acetylcholine through m4 subtype as wel as m2 and m3 subtypes in guinea-pig sto-mach.
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