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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 292 - 299 (8page)
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초록· 키워드
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Epidermal keratinocyte differentiation is a tightly
regulated stepwise process that requires protein
kinase C (PKC) activation. Studies on cultured
mouse keraitnocytes induced to differentiate
w ith Ca2+ have indirectly implicated the involvement
of PKCα isoform. When PKCα was overexpressed
in undifferentiated keratinocytes using
adenoviral system, expressions of differentiation
markers such as loricrin, filaggrin,
keratin 1 (MK1) and keratin 10 (MK10) were increased,
and ERK1/2 phosphorylation was concurrently
induced without change of other MAPK
such as p38 MAPK and JNK1/2. Similarly, transfection
of PKCα kinase active mutant (PKCα-
CAT) in the undifferentiated keratinocyte, but
not PKCβ-CAT, also increased differentiation
marker expressions. On the other hand, PKCα
dominant negative mutant (PKCβ-KR) reduced
Ca2+-mediated differentiation marker expressions,
while PKCβ-KR did not, suggesting that PKCα
is responsible for keratinocyte differentiation.
When downstream pathway of PKCα in Ca2+-
mediated differentiation was examined, ERK1/2,
p38 MAPK and JNK1/2 phosphorylations were
increased by Ca2+ shift. Treatment of keratinocytes
with PD98059, MEK inhibitor, and SB20358,
p38 MAPK inhibitor, before Ca2+ shift induced
morphological changes and reduced expressions
of differentiation markers, but treatment
with SP60012, JNK1/2 inhibitor, did not change
at all. Dominant negative mutants of ERK1/2 and
p38 MAPK also inhibited the expressions of
differentiation marker expressions in Ca2+ shifted
cells. The above results indicate that both
ERK1/2 and p38 MAPK may be involved in Ca2+-
mediated differentiation, and that only ERK1/2
pathway is specific for PKCα-m ediated differentiation
in mouse keratinocytes.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ / Alterations in murine keratinocyte differentiationinduced by activated rasHa genes are mediated byprotein kinase C-alpha : 6413 ~ 20
/ / Calcium regulation of growth and differentiationof mouse epidermal cells in culture : 245 ~ 54
/ / Coordinate changes in geneexpression which mark the spinous to granular cell transitionin epidermis are regulated by protein kinase C : 217 ~ 25
/ / Inhibition of v-rafdependentc-fos expression and transformation by a kinasedefectivemutant of the mitogen-activated protein kinaseErk2 : 4815 ~ 24
/ / Modulation of tissues and epidermaltransglutaminases in mouse epidermal cells after treatmentwith 12-O-tetradecanylphorbol-13-acetate and/or retinoic acidin vivo and in
/ / Calcium regulation of growth and differentiationof mouse epidermal cells in culture : 245 ~ 54
/ / Coordinate changes in geneexpression which mark the spinous to granular cell transitionin epidermis are regulated by protein kinase C : 217 ~ 25
/ / Inhibition of v-rafdependentc-fos expression and transformation by a kinasedefectivemutant of the mitogen-activated protein kinaseErk2 : 4815 ~ 24
/ / Modulation of tissues and epidermaltransglutaminases in mouse epidermal cells after treatmentwith 12-O-tetradecanylphorbol-13-acetate and/or retinoic acidin vivo and in
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