지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 529 - 535 (7page)
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초록· 키워드
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Oxidative stress such as reactive oxygen species (ROS) within the inflamed joint have been indicated as being involved as inflammatory mediators in the induction of arthritis. Correlations between extracellular-superoxide dismutase (EC-SOD) and inflammatory arthritis have been shown in several animal odels of RA. However, there is a question whether the over-expression of EC-SOD on arthritic joint also could suppress the progression of disease or not. In the present study, the effect on the synovial tissue of experimental arthritis was investigated using EC-SOD over-expressing transgenic mice. The over-expression of EC- SOD in joint tissue was confirmed by RT-PCR and immunohistochemistry. The degree of the inflammation in EC-SOD transgenic mice was suppressed in the collagen-induced arthritis model. In a cytokine assay, the production of pro-inflammatory cytokines such as, IL-1β, TNFα, and matrix metalloproteinases (MMPs) was decreased in fibroblast-like synoviocyte (FLS) but not in peripheral blood.
Histological examination also showed repressed cartilage destruction and bone in EC-SOD transgenic mice. In conclusion, these data suggest that the over-expression of EC-SOD in FLS contributes to the activation of FLS and protection from joint destruction by depressing the production of the pro-inflammatory cytokines and MMPs. These results provide EC-SOD transgenic mice with a useful animal model for inflammatory arthritis research.
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참고문헌 (23)
참고문헌 신청
Ago T / 2004 / Nox4 as the major catalytic component of an endothelial NAD(P)H oxidase / Circulation 109 : 227 ~ 233
Bombara MP / 1993 / Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines / J Leukoc Biol 54 : 399 ~ 406
Burkhardt H / 1986 / Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collag
Carlsson LM / 1995 / Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia / Proc Natl Acad Sci USA 92 : 6264 ~ 6268
Chenevier-Gobeaux C / 2006 / Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor
Bombara MP / 1993 / Cell contact between T cells and synovial fibroblasts causes induction of adhesion molecules and cytokines / J Leukoc Biol 54 : 399 ~ 406
Burkhardt H / 1986 / Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collag
Carlsson LM / 1995 / Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia / Proc Natl Acad Sci USA 92 : 6264 ~ 6268
Chenevier-Gobeaux C / 2006 / Superoxide production and NADPH oxidase expression in human rheumatoid synovial cells: regulation by interleukin-1beta and tumour necrosis factor
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