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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 476 - 480 (5page)
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초록· 키워드
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CPTP1 is a nontransmembrane chicken protein tyro-sine phosphatase having 92% sequence homology to the coresponding 321 amino acids of human protein tyrosine phosphatase 1B (HPTP1B). Using anti-CPTP1 antibody, we identified CPTP1-like rat P T P 1 o f 5 1 k D a i n R a t - 1 a n d v-src-transformed Rat-1 fibroblasts. Here we show that CPTP1-like rat PTP1 binds to p60v-srcin vivo and CPTP1 also can asociate with p60v-src in cell lysate of v-src- transformed Rat-1 fibroblasts. Interaction betwen and p60v-src was reduced by vanadate treatment for 13 h due to down regulation of the protein level of p60v-srcin vivo. Interestingly, CPTP1-like rat PTP1 was coimunoprecipitated with a 70-kDa protein which has a posibility to be tyrosine- phosphorylated by p60v-srcin v-src-transformed Rat- 1 fibroblasts. These results suggest that HPTP1B- type PTPs may play an important role in p60src dependent signal pathway in eucaryotic cels.
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