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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 279 - 284 (6page)
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Rafts, cholesterol- and sphingolipid-rich membrane microdomains, have been shown to play an im-portant role in immune cell activation. More re-cently rafts were implicated in the signal trans-receptor (TNFR) family. In this study, we provide evidences that the raft microdomain has a crucial role in RANK (receptor activator of NF-κB) signaling. We found that the majority of the ectopically expressed RANK and substantial portion of endogenous TRAF2 and TRAF6 were detected in the low-den-sity raft fractions. In adition, TRAF6 association with rafts was increased by RANKL stimulation. The disruption of rafts blocked the TRAF6 trans-teraction betwen RANK and TRAF6. Our obser-vations demonstrate that proper RANK signaling requires the function of raft membrane microdo-mains.
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