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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 703 - 717 (15page)
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초록· 키워드
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Diverse signaling pathways have been proposed to regulate store-operated calcium entry (SOCE) in a wide variety of cell types. However, it still needs to be determined if all of these known pathways operate in a single cell type. In this study, we examined involvement of various signaling molecules in SOCE using human fibroblast cells (HSWP). Bradykinin (BK)-stimulated Ca2+ entry, previously shown to be via SOCE, is enhanced by the addition of vanadate, an inhibitor of tyrosine phosphatases. Furthermore, SOCE is regulated by cytochrome P-450, as demonstrated by the fact that the products of cytochrome P-450 activity (14,15 EET) stimulated SOCE while econazole, an inhibitor of cytochrome P450, suppressed BK-stimulated Ca2+ entry. In contrast, Ca2+ entry was unaffected by the guanylate cyclase inhibitor LY83583, or the membrane permeant cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP). Neither nitric oxide donors nor phorbol esters affected BK-stimulated Ca2+ entry. SOCE in HSWP cells is primarily regulated by tyrosine phosphorylation and the cytochrome P-450 pathway, but not by cyclic GMP, nitric oxide, or protein kinase C. Thus, multiple pathways do operate in a single cell type leading to the activation of Ca2+ entry and some of these signaling pathways are more prominently involved in regulating calcium entry in different cell types.
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참고문헌 (28)
참고문헌 신청
/ / A GTP-dependent step in the activation mechanism of capacitative calcium influx : 20737 ~ 40
/ / Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores : 783 ~ 9
/ / Agonist-induced Ca2+influx in human neutrophils is secondary to the emptying of intracellular calcium stores : 73
/ / Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner : 6290 ~ 8
/ / Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells : 10808 ~ 12
/ / Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores : 783 ~ 9
/ / Agonist-induced Ca2+influx in human neutrophils is secondary to the emptying of intracellular calcium stores : 73
/ / Angiotensin II stimulates protein-tyrosine phosphorylation in a calcium-dependent manner : 6290 ~ 8
/ / Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells : 10808 ~ 12
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