지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 354 - 361 (8page)
이용수
초록· 키워드
오류제보하기
To select candidate genes, we attempted to comparative analysis of protein levels between rheumatoid arthritis (RA) patients and healthy controls by two-dimensional electrophoresis (2-DE) and matrix-assisted laser desorption ionization mass spectrometry (MALDI-TOF-MS). We identified 17 proteins that showed up- or down-regulated spots in RA patients.
We found that coactosin-like1 (COTL1) were highly expressed in RA patients compared with healthy controls. We performed a case-control study to determine whether the COTL1 gene polymorphisms were associated with RA and systemic lupus erythematosus (SLE). The genotype frequency of c.-1124G＞T and the allelic frequency of c.484G＞A in RA patients, and the genotype frequency of c.484G＞A in SLE patients were significantly different from healthy controls (P = 0.009, 0.027, and 0.025, respectively). We also investigated the correlation with the levels of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibody in RA patients, and anti-nuclear antibodies (ANA) in SLE patients. The c.484G＞A polymorphism in RA patients has significant association with the levels of anti-CCP antibody (P = 0.03). Our findings demonstrated that c.-1124G＞T and c.
484G＞A polymorphisms of the COTL1 gene might be associated with the genetic susceptibility of autoimmune disorders.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)]
Arnett FC / 1988 / The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis / Arthritis Rheum 31 : 315 ~ 324
Bailey JM / 1999 / Biochemistry, Mechanism of Action, and Clinical Applications. In Prostaglandins Leukotrienes and Lipoxins, 1985, 583-91, Plenum Publishing Co, New York Bla
Bla?ss S / 2001 / The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis / Arthritis Rheum 44 : 761 ~ 771
Chae SC / 2004 / The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis / Immunol Lett 95 : 91 ~ 95
Arnett FC / 1988 / The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis / Arthritis Rheum 31 : 315 ~ 324
Bailey JM / 1999 / Biochemistry, Mechanism of Action, and Clinical Applications. In Prostaglandins Leukotrienes and Lipoxins, 1985, 583-91, Plenum Publishing Co, New York Bla
Bla?ss S / 2001 / The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis / Arthritis Rheum 44 : 761 ~ 771
Chae SC / 2004 / The polymorphisms of Th1 cell surface gene Tim-3 are associated in a Korean population with rheumatoid arthritis / Immunol Lett 95 : 91 ~ 95
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Serum concentrations of soluble 4-1BB and 4-1BB ligand correlated with the disease severity in rheumatoid arthritis
Experimental and Molecular Medicine
2004 .01
-
Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis
Experimental and Molecular Medicine
2009 .01
-
Association of the Human IL-28RA Gene Polymorphisms in a Korean Population with Asthma
Genomics & informatics
2006 .01
-
Association of FOXJ1 polymorphisms with systemic lupuserythematosus and rheumatoid arthritis in Korean population
Experimental and Molecular Medicine
2007 .01
-
류마티스 관절염 환자의 항산화 영양소 섭취상태와 생활습관
대한지역사회영양학회지
2008 .04
-
Anti-Cyclic Citrullinated Peptide(Anti-CCP) 측정에 대한 연구
대한임상검사과학회지
2007 .01
-
Identification of Human LRG1 Polymorphisms and Their Genetic Association with Rheumatoid Arthritis
Genomics & informatics
2008 .01
-
Interaction between Smoking and the STAB2 Gene in the Severity of Rheumatoid Arthritis
Genomics & informatics
2009 .01
-
Comparative Proteomic Analyses of Synovial Fluids and Serums from Rheumatoid Arthritis Patients
Journal of Microbiology and Biotechnology
2014 .01
-
Recapitulation of Candidate Systemic Lupus Erythematosus-Associated Variants in Koreans
Genomics & informatics
2016 .01
-
Farnesyl transferase 억제제인 YH3938 및 YH3945에 의한 Ras 발암원성 억제
생명과학회지
2010 .02
-
Review on the Analysis Methods of 226Ra and 228Ra in Groundwater
한국분석과학회 학술대회
2012 .05
-
Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis
Experimental and Molecular Medicine
2011 .01
-
Effects of retinoic acid isomers on apoptosis and enzymatic antioxidant system in human breast cancer cells
Nutrition Research and Practice
2009 .06
-
Effects of retinoic acid isomers on apoptosis and enzymatic antioxidant system in human breast cancer cells
Nutrition Research and Practice
2009 .06
-
감마분광분석기를 이용한 퇴적물 중 226Ra 회수율 평가 연구
한국분석과학회 학술대회
2016 .11
-
A genetic effect of IL-5 receptor a polymorphism in patients with aspirin-exacerbated respiratory disease
Experimental and Molecular Medicine
2013 .01
-
Ras GTPase 및 Ras GTPase activating protein과 사람의 질병
생명과학회지
2018 .09
-
Identification of novel urinary biomarkers for assessing disease activity and prognosis of rheumatoid arthritis
Experimental and Molecular Medicine
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0