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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 574 - 582 (9page)
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Although human telomerase catalytic subunit (TERT)has several cellular functions including telomere homeostasis,genomic stability, cell proliferation, and tumorigenesis,the molecular mechanism underlying anti-apoptosis regulated by TERT remains to be elucidated. Here, we show that ectopic expression of TERT in spontaneously immortalized human fetal fibroblast (HFFS) cells, which are a telomerase- and p53-positive, leads to increases of cell proliferation and transformation, as well as a resistance to DNA damage response and inactivation of p53 function. We found that TERT and a mutant TERT (no telomerase activity)induce expression of basic fibroblast growth factor (bFGF), and ectopic expression of bFGF also allows cells to be resistant to DNA-damaging response and to suppress activation of p53 function under DNA-damaging induction. Furthermore, loss of TERT or bFGF markedly increases a p53 activity and DNA-damage sensitivity in HFFS, HeLa and U87MG cells. Therefore,our findings indicate that a novel TERT-bFGF axis accelerates the inactivation of p53 and consequent increase of resistance to DNA-damage response.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Aylon Y / 2007 / Living with p53, Dying of p53 / Cell 130 : 597 ~ 600
Branca M / 2007 / Upregulation of telomerase (TERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papi
Cayuela ML / 2005 / The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression / EMBO J 6 : 268 ~ 274
Gorbunova V / 2002 / Expression of human telomerase (TERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced a
Greider CW / 1996 / Telomere length regulation / Annu Rev Biochem 65 : 337 ~ 365
Branca M / 2007 / Upregulation of telomerase (TERT) is related to the grade of cervical intraepithelial neoplasia, but is not an independent predictor of high-risk human papi
Cayuela ML / 2005 / The telomerase RNA component Terc is required for the tumour-promoting effects of Tert overexpression / EMBO J 6 : 268 ~ 274
Gorbunova V / 2002 / Expression of human telomerase (TERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced a
Greider CW / 1996 / Telomere length regulation / Annu Rev Biochem 65 : 337 ~ 365
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