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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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- 자료유형
- 학술저널
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- 2012.1
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Angiogenesis is a complex biological phenomenon crucial for a correct embryonic development and for post-natal growth. In adult life, it is a tightly regulated process confined to the uterus and ovary during the different phases of the menstrual cycle and to the heart and skeletal muscles after prolonged and sustained physical exercise. Conversly, angiogenesis is one of the major pathological changes associated with several complex diseases like cancer, atherosclerosis, arthritis,diabetic retinopathy and age-related macular degeneration. Among the several molecular players involved in angiogenesis, some members of VEGF family,VEGF-A, VEGF-B and placenta growth factor (PlGF), and the related receptors VEGF receptor 1(VEGFR-1, also known as Flt-1) and VEGF receptor 2(VEGFR-2, also known as Flk-1 in mice and KDR in human)have a decisive role. In this review, we describe the discovery and molecular characteristics of PlGF,and discuss the biological role of this growth factor in physiological and pathological conditions.
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참고문헌 (22)
참고문헌 신청
Achen MG / 1997 / Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development / Growth Factors 15 : 69 ~ 80
Adini A / 2002 / Placental growth factor is a survival factor for tumor endothelial cells and macrophages / Cancer Res 62 : 2749 ~ 2752
Arrick BA / 1991 / Inhibition of translation of transforming growth factor-β 3 mRNA by its 5' untranslated region / Mol Cell Biol 11 : 4306 ~ 4313
Autiero M / 2003 / Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 / Nat Med 9 : 936 ~ 943
Bais C / 2010 / PlGF blockade does not inhibit angiogenesis during primary tumor growth / Cell 141 : 166 ~ 177
Adini A / 2002 / Placental growth factor is a survival factor for tumor endothelial cells and macrophages / Cancer Res 62 : 2749 ~ 2752
Arrick BA / 1991 / Inhibition of translation of transforming growth factor-β 3 mRNA by its 5' untranslated region / Mol Cell Biol 11 : 4306 ~ 4313
Autiero M / 2003 / Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 / Nat Med 9 : 936 ~ 943
Bais C / 2010 / PlGF blockade does not inhibit angiogenesis during primary tumor growth / Cell 141 : 166 ~ 177
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