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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
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- 1 - 8 (8page)
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Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial dynamics is related to the pathogenesis of several human diseases, its molecular mechanism is not fully elucidated. In this study, we demonstrate the potential role of miR-27 in the regulation of mitochondrial dynamics. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3′-untranslated region. Expression of miR-27 results in the elongation of mitochondria as well as an increased mitochondrial membrane potential and mitochondrial ATP level. Our results suggest that miR-27 is a novel regulator affecting morphological mitochondrial changes by targeting MFF.
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참고문헌 (30)
참고문헌 신청
Ambros V / 2004 / The functions of animal microRNAs / Nature 431 : 350 ~ 355
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Calin GA / 2006 / MicroRNA signatures in human cancers / Nat Rev Cancer 6 : 857 ~ 866
Campello S / 2010 / Mitochondrial shape changes : orchestrating cell pathophysiology / EMBO Rep 11 : 678 ~ 684
Chen H / 2005 / Disruption of fusion results in mitochondrial heterogeneity and dysfunction / J Biol Chem 280 : 26185 ~ 26192
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116 : 281 ~ 297
Calin GA / 2006 / MicroRNA signatures in human cancers / Nat Rev Cancer 6 : 857 ~ 866
Campello S / 2010 / Mitochondrial shape changes : orchestrating cell pathophysiology / EMBO Rep 11 : 678 ~ 684
Chen H / 2005 / Disruption of fusion results in mitochondrial heterogeneity and dysfunction / J Biol Chem 280 : 26185 ~ 26192
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