지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 1 - 14 (14page)
이용수
초록· 키워드
오류제보하기
Toll-like receptors (TLRs) are pivotal components of the innate immune response, which is responsible for eradicating invading microorganisms through the induction of inflammatory molecules. These receptors are also involved in responding to harmful endogenous molecules and have crucial roles in the activation of the innate immune system and shaping the adaptive immune response. However, TLR signaling pathways must be tightly regulated because undue TLR stimulation may disrupt the fine balance between pro- and anti-inflammatory responses. Such disruptions may harm the host through the development of autoimmune and inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Several studies have investigated the regulatory pathways of TLRs that are essential for modulating proinflammatory responses. These studies reported several pathways and molecules that act individually or in combination to regulate immune responses. In this review,we have summarized recent advancements in the elucidation of the negative regulation of TLR signaling. Moreover, this review covers the modulation of TLR signaling at multiple levels, including adaptor complex destabilization, phosphorylation and ubiquitin-mediated degradation of signal proteins, manipulation of other receptors, and transcriptional regulation. Lastly,synthetic inhibitors have also been briefly discussed to highlight negative regulatory approaches in the treatment of inflammatory diseases.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Brentano F / 2005 / RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via toll-like receptor 3 / Arthritis Rheumat 52 : 265
Doyle SE / 2004 / Toll-like receptors induce a phagocytic gene program through p38 / J Exp Med 199 : 81 ~ 90
Hoshino K / 1999 / Cutting Edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product / J Immunol 16
Iwasaki A / 2004 / Toll-like receptor control of the adaptive immune responses / Nat Immunol 5 : 987 ~ 995
Kaisho T / 2006 / Toll-like receptor function and signaling / J Allergy Clin Immunol 117 : 979 ~ 987
Doyle SE / 2004 / Toll-like receptors induce a phagocytic gene program through p38 / J Exp Med 199 : 81 ~ 90
Hoshino K / 1999 / Cutting Edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product / J Immunol 16
Iwasaki A / 2004 / Toll-like receptor control of the adaptive immune responses / Nat Immunol 5 : 987 ~ 995
Kaisho T / 2006 / Toll-like receptor function and signaling / J Allergy Clin Immunol 117 : 979 ~ 987
이 논문의 저자 정보
최근 본 자료
댓글(0)
0