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- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis. Lenalidomide displayed a strong therapeutic effect in all these models of autoimmune/inflammatory diseases, while the effect of pomalidomide was less pronounced. In vitro experiments confirmed the immunosuppressive effect of both IMiDs on the proliferative response of stimulated human lymphocytes and on the balance of secreted cytokines toward an anti-inflammatory profile. We conclude that lenalidomide may offer a therapeutic opportunity against autoimmune/inflammatory diseases.
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참고문헌 (25)
참고문헌 신청
Cohen IR / 2014 / Activation of benign autoimmunity as both tumor and autoimmune disease immunotherapy : a comprehensive review / J Autoimmun 54 : 112 ~ 117
Davies FE / 2001 / Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma / Blood 98 : 210 ~ 216
Fakhoury M / 2014 / Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Croh
Ghobrial IM / 2003 / Management of thalidomide toxicity / J Support Oncol 1 : 194 ~ 205
Ginsburg PM / 2001 / Thalidomide treatment for refractory Crohn’s disease: a review of the history, pharmacological mechanisms and clinical literature / Ann Med 33 : 516 ~
Davies FE / 2001 / Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma / Blood 98 : 210 ~ 216
Fakhoury M / 2014 / Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Croh
Ghobrial IM / 2003 / Management of thalidomide toxicity / J Support Oncol 1 : 194 ~ 205
Ginsburg PM / 2001 / Thalidomide treatment for refractory Crohn’s disease: a review of the history, pharmacological mechanisms and clinical literature / Ann Med 33 : 516 ~
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