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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 133 - 139 (7page)
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초록· 키워드
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Angiopoietin-1 (Ang1) binds to and activates Tie2 receptor
tyrosine kinase. Ang1-Tie2 signal has been proposed
to exhibit two opposite roles in the controlling
blood vessels. One is vascular stabilization and the
other is vascular angiogenesis. There has been no answer
to the question as to how Tie2 induces two opposite
responses to the same ligand. Our group and Dr.
Alitalo’s group have demonstrated that trans-associated
Tie2 at cell-cell contacts and extracellular matrix
(ECM)-anchored Tie2 play distinct roles in the endothelial
cells. The complex formation depends on the presence
or absence of cell-cell adhesion. Here, we review
how Ang1-Tie2 signal regulates vascular maintenance
and angiogenesis. We further point to the unanswered
questions that must be clarified to extend our knowledge
of vascular biology and to progress basic knowledge
to the treatment of the diseases in which
Ang1-Tie2-mediated signal is central.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Adams RH / 2007 / Molecular regulation of angiogenesis and lymphangiogenesis / Nat Rev Mol Cell Biol 8 : 464 ~ 478
Asahara T / 1998 / Tie2 receptor ligands,angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization / Circ Res 83 : 233 ~ 240
Atkins GB / 2007 / Role of Kruppel-like transcription factors in endothelial biology / Circ Res 100 : 1686 ~ 1695
Audoy-Remus J / 2008 / Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiop
Batard P / 1996 / The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells / Blood 87 : 2212 ~ 2220
Asahara T / 1998 / Tie2 receptor ligands,angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization / Circ Res 83 : 233 ~ 240
Atkins GB / 2007 / Role of Kruppel-like transcription factors in endothelial biology / Circ Res 100 : 1686 ~ 1695
Audoy-Remus J / 2008 / Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiop
Batard P / 1996 / The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells / Blood 87 : 2212 ~ 2220
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