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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 465 - 472 (8page)
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Most of the previous studies on immune dysregulation in end-stage renal disease (ESRD) have focused on T cell immunity. We investigated B cell subpopulations in ESRD patients and the effect of hemodialysis (HD)on B cell-associated immune profiles in these patients.
Forty-four ESRD [maintenance HD patients (n = 27)and pre-dialysis patients (n = 17)] and 27 healthy volunteers were included in this study. We determined the percentage of B cell subtypes, such as mature and immature B cells, memory B cells, and interleukin (IL)-10+cells, as well as B cell-producing cytokines (IL-10, IL-4and IL-21) by florescent activated cell sorting (FACS).
B cell-associated gene expression was examined using real-time PCR and B cell producing cytokines (IL-10, IL-4 and IL-21) were determined using an enzyme-linked immunosorbent assay (ELISA). The percentage of total B cells and mature B cells did not differ significantly among the three groups. The percentages of memory B cells were significantly higher in the pre-dialysis group than in the HD group (P ＜ 0.01), but the percentage of immature B cells was significantly lower in the pre-dialysis group than in the other groups.
The percentages of IL-10-expressing cells that were CD19+ or immature B cells did not differ significantly (P ＞ 0.05) between the two subgroups within the ESRD group, but the serum IL-10 concentration was significantly lower in the pre-dialysis group (P ＜0.01). The results of this study demonstrate significantly altered B cell-associated immunity.
Specifically, an imbalance of immature and memory B cells in ESRD patients was observed, with this finding predominating in pre-dialysis patients.
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참고문헌 (25)
참고문헌 신청
Alvarez-Lara MA / 2004 / The imbalance in the ratio of Th1 and Th2 helper lymphocytes in uraemia is mediated by an increased apoptosis of Th1 subset / Nephrol Dial Transplant
Blair PA / 2010 / CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients /
Chiu CW / 2002 / BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins / EMBO J 21 : 6461 ~ 6472
Chung BH / 2012 / Increased interleukin-17 producing effector memory T cells in the end-stage renal disease patients / Immunol Lett 141 : 181 ~ 189
Ettinger R / 2008 / The role of IL-21 in regulating B-cell function in health and disease / Immunol Rev 223 : 60 ~ 86
Blair PA / 2010 / CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients /
Chiu CW / 2002 / BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins / EMBO J 21 : 6461 ~ 6472
Chung BH / 2012 / Increased interleukin-17 producing effector memory T cells in the end-stage renal disease patients / Immunol Lett 141 : 181 ~ 189
Ettinger R / 2008 / The role of IL-21 in regulating B-cell function in health and disease / Immunol Rev 223 : 60 ~ 86
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