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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 465 - 476 (12page)
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CXC chemokine receptor 4 (CXCR4), which binds the stromal cell-derived factor-1 (SDF-1), has been shown to play a critical role in mobilizing the bone marrow (BM)-derived stem cells and inflammatory cells. We studied the effects of AMD3100, CXCR4 antagonist, on a murine bleomycin-induced pulmonary fibrosis model. Treatment of mice with AMD3100 in bleomycin-treated mice resulted in the decrease of SDF-1 in bronchoalveolar lavage (BAL) fluids at an early stage and was followed by the decrease of fibrocytes in the lung. AMD3100 treatment decreased the SDF-1 mRNA expression, fibrocyte numbers in the lung at an early stage (day 3) and CXCR4 expression at the later stage (day 7 and 21) after bleomycin injury. The collagen content and pulmonary fibrosis were significantly attenuated by AMD3100 treatment in later stage of bleomycin injury. AMD3100 treatment also decreased the murine mesenchymal and hematopoietic stem cell chemotaxis when either in the stimulation with bleomycin treated lung lysates or SDF-1 in vitro. In BM stem cell experiments, the phosphorylation of p38 MAPK which was induced by SDF-1 was significantly blocked by addition of AMD3100. Our data suggest that AMD3100might be effective in preventing the pulmonary fibrosis by inhibiting the fibrocyte mobilization to the injured lung via blocking the SDF-1/CXCR4 axis.
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참고문헌 (23)
참고문헌 신청
Abe R / 2001 / Peripheral blood fibrocytes: differentiation pathway and migration to wound sites / J Immunol 166 : 7556 ~ 7562
Aiuti A / 1997 / The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ pro
Ashcroft T / 1988 / Simple method of estimating severity of pulmonary fibrosis on a numerical scale / J Clin Pathol 41 : 467 ~ 470
Bleul CC / 1996 / A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) / J Exp Med 184 : 1101 ~ 1109
Bucala R / 1994 / Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair / Mol Med 1 : 71 ~ 81
Aiuti A / 1997 / The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ pro
Ashcroft T / 1988 / Simple method of estimating severity of pulmonary fibrosis on a numerical scale / J Clin Pathol 41 : 467 ~ 470
Bleul CC / 1996 / A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) / J Exp Med 184 : 1101 ~ 1109
Bucala R / 1994 / Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair / Mol Med 1 : 71 ~ 81
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