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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 849 - 855 (7page)
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초록· 키워드
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In this study, we have shown that gene expression of human GD3 synthase (hST8Sia I) is suppressed by triptolide (TPL) in human melanoma SK-MEL-2 cells. To elucidate the mechanism underlying the downregulation of hST8Sia I gene expression in TPL-treated SK-MEL-2 cells, we characterized the TPL-inducible promoter region within the hST8Sia I gene using luciferase constructs carrying 5’-deletions of the hST8Sia I promoter. Functional analysis of the 5’-flanking region of the hST8Sia I gene demonstrated that the -1146to -646 region, which contains putative binding sites for transcription factors c-Ets-1, CREB, AP-1 and NF-κB, functions as the TPL-inducible promoter of hST8Sia I in SK-MEL-2 cells. Site-directed mutagenesis and ChIP analysis indicated that the NF-κB binding site at -731 to -722 is crucial for TPL-induced suppression of hST8Sia I in SK-MEL-2 cells. This suggests that TPL induces down-regulation of hST8Sia I gene expression through NF-κB activation in human melanoma cells.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Baeuerle PA / 1996 / NF-κB: ten years after / Cell 87 : 13 ~ 20
Brinker AM / 2007 / Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) / Phytochemistry 68 : 732 ~ 766
Carter BZ / 2006 / Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells / Blood 108 : 630 ~ 637
Chang HJ / 2007 / Triptolide inhibits tumor promoterinduced uPAR expression via blocking NF-κB signaling in human gastric AGS cells / Anticancer Res 27 : 3411 ~ 3417
Chen BJ / 2001 / Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F / Leuk Lymphoma 42 : 253 ~ 265
Brinker AM / 2007 / Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae) / Phytochemistry 68 : 732 ~ 766
Carter BZ / 2006 / Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells / Blood 108 : 630 ~ 637
Chang HJ / 2007 / Triptolide inhibits tumor promoterinduced uPAR expression via blocking NF-κB signaling in human gastric AGS cells / Anticancer Res 27 : 3411 ~ 3417
Chen BJ / 2001 / Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F / Leuk Lymphoma 42 : 253 ~ 265
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